Effect of (Korth.) Steud. leaf extract on hematological and histopathological changes in liver and kidney of striped catfish infected by .

Aim: The present study was conducted to investigate the efficacy of different doses of Bangkal () leaf extract on hematological and histological changes in kidney and liver of catfish () infected by .

Materials And Methods: Catfish were experimentally infected with at a dose of 10 cells/mL through intraperitoneal injection, and the hematological and histological changes in the kidney and liver of catfish against the pathogen were observed.

Results: Not all concentrations of caused a toxic effect in striped catfish. The clinical symptoms of catfish after infection with and treatment with leaf extract included morphological and behavioral changes. leaf extract reduced mortality caused by . Treatment with leaf extract was effective in reducing the inflammation by decreasing the activity of neutrophils, monocytes, and lymphocytes. The Hb and Ht levels of catfish significantly decreased after exposure to 10 cells/mL of and increased significantly after treatment. Necrosis percentages in the kidney and liver also decrease after treatment.

Conclusion: The results indicate that leaf extract stimulates the immunity and increases the resistance of catfish to leaf extract may be used as a potential source for future drug development and food applications.