AI Article Synopsis
- Rhodococcus equi is a veterinary pathogen that is developing resistance to current antibiotics, making it harder to treat infections.
- Researchers studied the extracellular thioredoxin (Etrx3) to understand its role in helping the bacteria survive inside immune cells known as macrophages.
- Their findings indicated that without Etrx3, R. equi couldn't survive in macrophages and was more susceptible to certain oxidative agents, highlighting Etrx3's importance in the bacteria's resistance mechanisms.
Article Abstract
Rhodococcus equi is an intracellular veterinary pathogen that is becoming resistant to current antibiotherapy. Genes involved in preserving redox homeostasis could be promising targets for the development of novel anti-infectives. Here, we studied the role of an extracellular thioredoxin (Etrx3/REQ_13520) in the resistance to phagocytosis. An etrx3-null mutant strain was unable to survive within macrophages, whereas the complementation with the etrx3 gene restored its intracellular survival rate. In addition, the deletion of etrx3 conferred to R. equi a high susceptibility to sodium hypochlorite. Our results suggest that Etrx3 is essential for the resistance of R. equi to specific oxidative agents.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063783 | PMC |
| http://dx.doi.org/10.1186/s13567-020-00763-3 | DOI Listing |
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