AI Article Synopsis
- The study aimed to assess how thyroid hormones in follicular fluid affect the number of oocytes retrieved during assisted fertilization procedures.
- A group of 51 women aged 29-42 underwent ovarian stimulation, with thyroid hormone levels measured in the follicular fluid after oocyte retrieval.
- Results indicated that higher levels of T4 in follicular fluid positively correlated with the number of oocytes collected, suggesting a link between thyroid function and ovarian development.
Article Abstract
Objective: Our aim was to analyze the role of thyroid hormones in follicular fluid (FF) in relation to the number of oocytes retrieved in women recruited for an assisted fertilization procedure.
Methods: Retrospective cohort study of 51 women 37.5±3.3 years, range 29-42, evaluated after a controlled ovarian stimulation protocol in a University Hospital. FF was sampled by transvaginal ultrasound-guided aspiration after ovarian hyperstimulation and we measured T3 (T3f), T4 (T4f), TSH (TSHf) and free T4 (T4ff). The oocyte maturation rate was calculated as: Number of metaphase II oocytes/Number of oocytes retrieved x 100. Statistical analysis was performed using the SPSS-19 software.
Results: Hormone levels in FF were: TSHf 1.3µIU/ml (0.4 - 2.7), T3f: 1.52±0.46 nmol/L, T4f 88.8±30.9nmol/L and T4ff: 15.44±2.57pmol/L. The number of oocytes recovered was dependent onT4f following the equation: Log (oocyte) = 0.379+0.042*T4f (r:0.352, p=0.012). After a logistic regression model analysis, T3f showed a tendency to be associated with the OMR: OR (95 % CI)= 0.977 (0.954 to 1.001), p=0.057.
Conclusions: The correlation found between thyroid hormones and the number of oocytes retrieved suggests an interaction between thyroid and gonadal axes in relation to follicular development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365548 | PMC |
| http://dx.doi.org/10.5935/1518-0557.20200004 | DOI Listing |
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