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Mutational Landscape of Proto-Oncogene Coding Sequence in 62 Canine Cutaneous and Subcutaneous Mast Cell Tumors.
Vet Sci
November 2024
Department of Comparative Biomedicine and Food Science, University of Padua, Viale dell'Università 16, I-35020 Legnaro, Italy.
Canine mast cell tumors (MCTs) are common skin neoplasms with varying biological behaviors. The proto-oncogene plays a key role in the development of these tumors, and internal tandem duplications on exon 11 are usually associated with more aggressive behavior, increased local recurrence, and decreased survival time. However, apart from exons 8-11 and 17, there is limited understanding of the overall mutational landscape in canine MCTs.
View Article and Find Full Text PDFThe Beneficial Roles of Seaweed in Atopic Dermatitis.
Mar Drugs
December 2024
Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea.
Atopic dermatitis (AD) is a chronic, inflammatory skin condition characterized by severe pruritus and recurrent flare-ups, significantly impacting patients' quality of life. Current treatments, such as corticosteroids and immunomodulators, often provide symptomatic relief but can lead to adverse effects with prolonged use. Seaweed, a sustainable and nutrient-dense resource, has emerged as a promising alternative due to its rich bioactive compounds-polysaccharides, phlorotannins, polyphenols, and chlorophyll-that offer anti-inflammatory, antioxidant, and immunomodulatory properties.
View Article and Find Full Text PDFSkin Microbiota, Circulating Metabolic Biomarker, Epilepsy: A Mendelian Randomization Analysis.
Curr Issues Mol Biol
December 2024
School of Artificial Intelligence, Hangzhou Dianzi University, Hangzhou 310018, China.
Epilepsy is a neurological disorder characterized by recurrent, unprovoked seizures. Currently, the associations among skin microbiota, circulating metabolites, and epilepsy are still not well studied. In this study, we applied univariate and two-step Mendelian randomization analysis using single nucleotide polymorphisms as instrumental variables to analyze the possible associations.
View Article and Find Full Text PDFGiant Primary Cutaneous Nodular Melanoma of the Forehead: A Case Report.
Geriatrics (Basel)
December 2024
Medicine for Older People, University Hospital Southampton, Tremona Road, Southampton SO16 6YD, UK.
The incidence of melanoma is increasing globally. The estimated worldwide incidence is projected to increase from 324,635 cases in 2020 to 510,000 in 2040. In the UK, melanoma accounts for 4% of all new cases of cancer.
View Article and Find Full Text PDFBraf-Mutant Melanomas: Biology and Therapy.
Curr Oncol
December 2024
Department of Oncology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
The incidence of melanoma, the most lethal form of skin cancer, has increased mainly due to ultraviolet exposure. The molecular characterization of melanomas has shown a high mutational burden led to the identification of some recurrent genetic alterations. gene is mutated in 40-50% of melanomas and its role in melanoma development is paramount.
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