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Daratumumab plus lenalidomide/dexamethasone in untreated multiple myeloma: analysis of key subgroups of the MAIA study.
Leukemia
January 2025
Department of Hematology, Mayo Clinic Rochester, Rochester, MN, USA.
In the MAIA study (median follow-up, 56.2 months), daratumumab plus lenalidomide and dexamethasone (D-Rd) significantly improved progression-free survival (PFS) and overall survival versus lenalidomide and dexamethasone (Rd) alone in transplant-ineligible newly diagnosed multiple myeloma (NDMM). In this post hoc analysis of clinically important subgroups in MAIA (median follow-up, 64.
View Article and Find Full Text PDFIncidence, risk factors, and outcomes of transplant-associated thrombotic microangiopathy in pediatric patients after allogeneic hematopoietic cell transplantation: a single-institution prospective study.
Bone Marrow Transplant
January 2025
Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Transplant-associated thrombotic microangiopathy (TA-TMA) is an increasingly recognized complication in hematopoietic cell transplantation (HCT). Given the rarity of prospective pediatric studies on TA-TMA, this study aimed to evaluate the incidence, survival outcomes, and risk factors for predicting early the development of TA-TMA in a pediatric population following allogeneic HCT. We conducted a prospective analysis of 173 pediatric patients to evaluate the incidence, survival outcome, and risk factors of TA-TMA.
View Article and Find Full Text PDFDetermining anatomically-safe corridors for placement of lateral mass screws in the first cervical vertebra of the Emirati population - a CT study.
Sci Rep
January 2025
College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai, UAE.
The first cervical vertebra (C1) is atypical in shape and bears a complex relationship with important neurovascular structures such as the vertebral artery and cervical spinal cord which are at risk of injury during misplaced screw fixation of C1. Placement of screws into the lateral mass of C1 vertebra is performed for stabilization of the craniovertebral junction. The objective of this study was to describe ideal screw dimensions, precise entry points, safe bony corridors, and ideal trajectories for placement of lateral mass screws in the Emirati population.
View Article and Find Full Text PDFRethinking Repeat Two-Stage Knee Exchange Arthroplasty: Outcomes, Risks, and Decision-Making.
J Arthroplasty
January 2025
Department of Orthopaedic Surgery, Chang Gung Memorial Hospital (CGMH), No. 5 Fu-Hsing Street, Kweishan, Taoyuan, Taiwan; Bone and Joint Research Center, Chang Gung Memorial Hospital (CGMH), No. 5 Fu-Hsing Street, Kweishan, Taoyuan, Taiwan; College of Medicine, Chang Gung University (CGU), 259 Wen-Hwa 1st Road, Kweishan, Taoyuan, Taiwan. Electronic address:
Background: Chronic periprosthetic joint infection (PJI) presents a major challenge in knee arthroplasty, with varying success rates reported for two-stage exchange arthroplasty (EA) and a lack of consensus on managing failures from such procedures. This study evaluated repeat two-stage EA outcomes for knee PJI after initial treatment failure to identify the risk factors for reimplantation unsuitability and reinfection.
Methods: We analyzed 114 patients who underwent repeat EA for chronic knee PJI between 2010 and 2018.
A rare pediatric case of thoracic spine giant cell tumor: Clinical implications and surgical strategies.
Int J Surg Case Rep
January 2025
Department of Neurosurgery, Damascus Hospital, Damascus, Syria; Faculty Of Medicine, Al-fourat university, Deir ez-Zor, Syria.
Introduction And Clinical Importance: Giant cell tumor (GCT) is a rare benign bone tumor that usually affects skeletally adult people. While it usually appears in the epiphyseal parts of long bones, it is very rare in the spine, particularly the thoracic spine, especially in pediatric patients.
Case Presentation: An 11-year-old female presented with progressive lower extremity weakness, accompanied by localized back pain and urinary urgency, diagnosed with GCT in the thoracic spine.
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