A new family of chiral symmetric tetraazamacrocycles, coined ISAC for IminoSugar Aza-Crown, incorporating two iminosugars adopting a C conformation is disclosed. Multinuclear NMR experiments on the corresponding Cd complex show that the ISAC is a strong chelator in water and its tetramine cavity adopts a conformation similar to that of the parent Cd-cyclam complex. Similar behavior is observed with Cu in solution, with enhanced stability compared to the Cu-cyclam complex.
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| http://dx.doi.org/10.1021/acs.orglett.0c00503 | DOI Listing |
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