AI Article Synopsis
- * The parasites infect macrophages in mammals, where they thrive by causing an immunosuppressive environment that aids in their survival and progression of the disease.
- * Variations in immune responses and differing interactions with Leishmania species affect the success of vaccines, diagnostic methods, and treatments for leishmaniasis.
Article Abstract
Leishmaniasis is a disease complex caused by 20 species of protozoan parasites belonging to the genus Leishmania. In humans, it has two main clinical forms, visceral leishmaniasis (VL) and cutaneous or tegumentary leishmaniasis (CL), as well as several other cutaneous manifestations in a minority of cases. In the mammalian host Leishmania parasites infect different populations of macrophages where they multiply and survive in the phagolysosomal compartment. The progression of both VL and CL depends on the maintenance of a parasite-specific immunosuppressive state based around this host macrophage infection. The complexity and variation of immune responses and immunopathology in humans and the different host interactions of the different Leishmania species has an impact upon the effectiveness of vaccines, diagnostics and drugs.
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| http://dx.doi.org/10.1007/s00281-020-00788-y | DOI Listing |
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