AI Article Synopsis
- Vitamin D plays a role in brain health, and this study focused on its relationship with brain volume in older adults.
- Researchers measured the serum concentration of 25-hydroxyvitamin D (25OHD) in 53 participants and analyzed their gray matter volume using specialized imaging software.
- Results showed that lower levels of 25OHD were linked to reduced gray matter volume in the calcarine sulcus, indicating potential atrophy in older adults with insufficient vitamin D levels.
Article Abstract
Vitamin D is involved in brain health and function. Our objective was to determine whether lower 25-hydroxyvitamin D (25OHD) concentration was associated with focal brain volume reduction in older adults. Serum 25OHD concentration was measured among 53 older adults (72 ± 5 years; 38% female; mean 25OHD = 67.3 ± 20.8 nmol/L). Gray matter volume (GMV) was automatically segmented using voxel-based morphometry with CAT12 software. Covariables were age, gender, education, total intracranial volume, and season. Serum 25OHD was positively associated with GMV in left calcarine sulcus (P < 0.05, TFCE, FWE-corrected). We found atrophy of the calcarine sulcus with lower 25OHD concentrations in older adults.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187697 | PMC |
| http://dx.doi.org/10.1002/acn3.50997 | DOI Listing |
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