Polygoni multiflori Radix Praeparata (PMRP) is a traditional medicine used for nourishing essence and blood in China. However, it is unclear which PMRP compounds are responsible for its hematopoietic effect. In this study, spectrum-effect relationship was used to discovery potential hematopoietic compounds. The fingerprints of 20 PMRP batches were established by HPLC and the hematopoietic effect was determined using red blood cell, hemoglobin, hematocrit, and platelet indexes in aplastic anemia model mice. The spectrum-effect relationship between common peaks and hematopoietic efficacy values was established using gray relational analysis and partial least squares analysis. Spectrum-effect relationship results showed that peaks 21 (emodin-8-O-(6´-O-acetyl)-β-D-glucoside), 15 (2, 3, 5, 4'-tetrahydroxystilbene-2-O-di-glucoside), 16 (cis-2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside), 11 (unknown), 20(unknown, 12 (epicatechin), 29 (carboxyl emodin), and 31 (emodin) in the fingerprints were closely related to the hematopoietic effect. This work successfully established the spectrum-effect relationship between PMRP hematopoietic effect and its fingerprints, which can be used to explain the material basis for the PMRP hematopoietic effect.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/bmc.4821 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Identification of components that increase NAD+ levels in oxygen-glucose deprived HUVEC s from Schisandra chinensis (Turcz.) Baill. Based on spectrum-effect correlation analysis and target cell extraction.
Fitoterapia
December 2024
Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China. Electronic address:
Schisandra chinensis (Turcz.) Baill, a traditional Chinese medicine with significant nourishing functions, has a regulatory effect on the cardiovascular system, digestive system, central nervous system, and endocrine and immune systems. It can protect the cardiovascular system, improve immunity, and has anti-oxidant and anti-aging properties.
View Article and Find Full Text PDFCorrection: A rapid evaluation method for the quality consistency assessment and spectrum-effect relationship study of Xiaohuoluo Pills developed based on combined spectral and chromatography technology.
Anal Methods
December 2024
Department of Clinical Pharmacy, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Article Synopsis
- The correction addresses inaccuracies in the original research regarding the evaluation method for Xiaohuoluo Pills, focusing on the quality consistency and spectrum-effect relationship.
- It highlights the significance of using combined spectral and chromatography technology in assessing the herbal medication's effectiveness.
- The authors clarify the methodology, providing updated data and explanations to enhance understanding and reliability of the study's findings.
Cremastrae Pseudobulbus Pleiones Pseudobulbus (CPPP) Against Non-Small-Cell Lung Cancer: Elucidating Effective Ingredients and Mechanism of Action.
Pharmaceuticals (Basel)
November 2024
School of Chinese Medica Materia, Beijing University of Chinese Medicine, Beijing 100029, China.
Cremastrae Pseudobulbus Pleiones Pseudobulbus (CPPP) is derived from the dried pseudobulb of the orchid family plants (D.Don) Makino, (Franch.) Rolfe, or Rolfe, and has the properties of clearing heat, detoxification, resolving phlegm, and dispersing nodules.
View Article and Find Full Text PDFExploration the effective components of Gastrodia elata in improving cerebral ischemia reperfusion injury based on "Spectrum-effect" correlation and zebrafish verification experiment.
Phytomedicine
December 2024
School of pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, PR China; Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei 230012, PR China; Resources Protection and Development Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement, Hefei 230012, PR China; Anhui Province Key Laboratory of Traditional Chinese Medicine Decoction Pieces of New Manufacturing Technology, Bozhou, PR China. Electronic address:
Background: Gastrodia elata (GE) has been widely used in clinical practice for many years with the functions of relieving stroke, suppressing liver Yang, dispelling wind and clearing collaterals. Our group's previous experimental studies have proved that GE has therapeutic effect on cerebral ischemia reperfusion injury (CIRI) (Ding et al., 2022).
View Article and Find Full Text PDFSpectrum-effect relationship between HPLC fingerprints and antioxidant activities of Bletilla striata.
J Chromatogr B Analyt Technol Biomed Life Sci
November 2024
School of Pharmacy, Xi'an Jiaotong University, Xi'an, PR China. Electronic address:
Article Synopsis
- Bletilla striata is a perennial herb known for its medicinal properties, including promoting wound healing and having anti-inflammatory and antioxidant effects.
- This study used chemometric methods to analyze the relationship between the chemical composition of 20 different extracts of Bletilla striata and their antioxidant activities, revealing significant variations in quality among samples.
- Key compounds identified, such as coelonin, gymnoside IX, and dactylorhin A, were found to have strong correlations with antioxidant activity, providing valuable insights for future quality evaluation and control of this herb.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!