In multi-instance learning (MIL), labels are associated with bags rather than the instances in the bag. Most of the previous MIL methods assume that each bag has the actual label in the training set. However, from the process of labeling work, the label of a bag is always evaluated by the calculation of the labels obtained from a number of labelers. In the calculation, the weight of each labeler is always unknown and people always assign the weight for each labeler by random or equally, and this may result in the ambiguous labels for the bags, which is called weak labels here. In addition, we always meet the problem of knowledge transfer from the source task to the target task, and this leads to the study of multiple instance transfer learning. In this article, we propose a new framework called transfer learning-based multiple instance learning (TMIL) framework to address the problem of multiple instance transfer learning in which both the source task and the target task contain the weak labels. We first construct a TMIL model with weak labels, which can transfer knowledge from the source task to the target task where both source and target tasks contain weak labels. We then put forward an iterative framework to solve the transfer learning model with weak labels so that we can update the label of the bag to improve the performance of multiple instance learning. We then present the convergence analysis of the proposed method. The experiments show that the proposed method outperforms the existing multiple instance learning methods and can correct the initial labels to obtain the actual labels for the bags.
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http://dx.doi.org/10.1109/TCYB.2020.2973450 | DOI Listing |
Cancers (Basel)
January 2025
Department of Biomedical Engineering, Division of Oncological Sciences, Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97201, USA.
Cell surface receptors are pivotal to cancer cell transformation, disease progression, metastasis, early detection, targeted therapy, drug responses, and clinical outcomes. Since they coordinate complex signaling communication networks in the tumor microenvironment, mapping the physical interaction partners of cell surface receptors in vivo is vital for understanding their roles, functional states, and suitability as therapeutic targets. Yet traditional methods like immunoprecipitation and affinity purification-mass spectrometry often fail to detect key but weak or transient receptor-protein interactions.
View Article and Find Full Text PDFUltrasound Obstet Gynecol
January 2025
Robinson Research Institute, University of Adelaide, Adelaide, Australia.
Objectives: The development of valuable artificial intelligence (AI) tools to assist with ultrasound diagnosis depends on algorithms developed using high-quality data. This study aimed to test the intra- and interobserver agreement of a proposed image-quality scoring system to quantify the quality of gynecological transvaginal ultrasound (TVS) images, which could be used in clinical practice and AI tool development.
Methods: A proposed scoring system to quantify TVS image quality was created following a review of the literature.
Clin Exp Allergy
January 2025
School of Infection, Inflammation and Immunology, University of Birmingham, Brimingham, UK.
Data regarding Penicillin allergy labels (PALs) from India and Sri Lanka are sparse. Emerging data suggests that the proportion of patients declaring an unverified PAL in secondary care in India and Sri Lanka (1%-4%) is lesser than that reported in High Income Countries (15%-20%). However, even this relatively small percentage translates into a large absolute number, as this part of the world accounts for approximately 25% of the global population.
View Article and Find Full Text PDFJ Imaging Inform Med
January 2025
Department of Electrical and Computer Engineering, Duke University, Durham, NC, USA.
Deep neural networks (DNNs) have demonstrated exceptional performance across various image segmentation tasks. However, the process of preparing datasets for training segmentation DNNs is both labor-intensive and costly, as it typically requires pixel-level annotations for each object of interest. To mitigate this challenge, alternative approaches such as using weak labels (e.
View Article and Find Full Text PDFJ Phys Chem B
January 2025
Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.
Intermolecular hydrogen bonds between carboxyl (COO) and amino groups are a common weak interaction in proteins. Infrared (IR) spectral assignment of such an intermolecular hydrogen bond provides a fingerprint for studying protein-protein interactions as its absorption frequency is affected by the molecular electrostatic environment. Temperature-dependent FTIR and temperature-jump time-resolved IR absorbance difference spectra of several typical amino acids and those of wild type and single-site mutated αB-crystallin were performed.
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