Objective: To investigate whether the polymorphisms of interleukin-12B () were associated with the risk of developing colorectal cancer (CRC). . Genotypes of rs17860508 and rs3212227 were determined by polymerase chain reaction with a direct sequencing method in 329 CRC patients and 342 matched healthy control subjects. The expression of ) were associated with the risk of developing colorectal cancer (CRC).
Results: Compared with TTAGAG/TTAGAG genotype of rs17860508, the GC/GC and TTAGAG/GC genotypes may significantly increase the risk of CRC (OR = 1.81, 95% CI = 1.18-2.78; OR = 1.46, 95% CI = 1.01-2.12, respectively). Furthermore, the mRNA levels of ) were associated with the risk of developing colorectal cancer (CRC). =0.009) and TTAGAG/TTAGAG (=0.009) and TTAGAG/TTAGAG (.
Conclusion: These data suggested that the rs17860508 GC/GC genotype might upregulate expression at the transcriptional level and thus increase the risk of CRC.) were associated with the risk of developing colorectal cancer (CRC).
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| http://dx.doi.org/10.1155/2020/2091781 | DOI Listing |
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