Objectives: To investigate the effect of systemic administration of the immunosuppressant dexamethasone (DM) while inducing hamster buccal pouch DMBA carcinogenesis. . Two different experiments were performed. In the first experiment, hamsters' right buccal pouches in group A ( = 10) were painted three times per week with 7,12-dimethylbenzanthracene (DMBA) 0.5%, while pouches of animals in group B ( = 10) were painted three times per week with 7,12-dimethylbenzanthracene (DMBA) 0.5%, while pouches of animals in group B (.
Results: The time of macroscopic neoplasm development was reduced when DM-DMBA coexposition was employed, finding tumors after 10-12 weeks of exposition. In addition, the frequency of histopathological lesions was higher.
Conclusion: Immunomodulatory action of dexamethasone may reduce the time of oral squamous cell carcinoma (OSCC) induction and may increase the incidence of neoplasms developed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042540 | PMC |
| http://dx.doi.org/10.1155/2020/1470868 | DOI Listing |
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Studies on the relationship between treatment condition and micronucleus induction in V79 cells exposed to silica and glass fibers.
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Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, USA.
Studies have been carried out to determine the relationship between treatment condition and frequencies of micronucleated cells (MNC) and multinucleated cells (MTC) in Chinese hamster lung fibroblasts (V79 cells) exposed to dusts and fibers. Cells were treated with Min-U-Sil 5 silica or Owens Corning AAA-10 glass fibers under three different conditions: 24-h exposure (24E), 24-h exposure followed by 24-h post-incubation in fresh medium (24E-24P), and 48-h exposure (48E). Results showed that the frequency of MNC increased in a concentration-related manner in silica-treated V79 cells only under the condition of 24E-24P.
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