AI Article Synopsis
- Almost all human diseases are linked to inflammation, making it crucial to understand the mechanisms behind it for effective treatments.
- The NLRP3 inflammasome, made up of the NLRP3 protein, procaspase-1, and ASC, is key in regulating inflammatory responses.
- This review focuses on how NLRP3 is activated, its role in inflammatory diseases, its relationship with autophagy, and the potential therapeutic strategies targeting NLRP3 in these conditions.
Article Abstract
Almost all human diseases are strongly associated with inflammation, and a deep understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome composed of the NLRP3 protein, procaspase-1, and ASC plays a vital role in regulating inflammation. In this review, NLRP3 regulation and activation, its proinflammatory role in inflammatory diseases, interactions with autophagy, and targeted therapeutic approaches in inflammatory diseases will be summarized.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049400 | PMC |
| http://dx.doi.org/10.1155/2020/4063562 | DOI Listing |
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