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What is a cure through gene therapy? An analysis and evaluation of the use of "cure".
Med Health Care Philos
December 2024
Department of Bioethics and Health Humanities, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Article Synopsis
- The paper explores the concept of "cure" in gene therapy, particularly for hemophilia, highlighting the ambiguity surrounding its meaning in medical discussions.
- It identifies three interpretations of "cure": normalization of the body, achieving a normal life, and a change in identity, arguing that context is key for each use.
- The authors suggest that in gene therapy, it's more effective to move away from the term "cure" and adopt more specific definitions to guide health resource decisions and research funding.
Meaning and prediction of 'excess mortality': a comparison of Covid-19 and pre-Covid-19 mortality data in 31 Eurostat countries from 1965 to 2021.
Biol Methods Protoc
May 2024
Institute for Sociology, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany.
Determining 'excess mortality' makes it possible to compare the burden of disasters between countries and over time, and thus also to evaluate the success of mitigation measures. However, the debate on coronavirus disease 2019 (Covid-19) has exposed that calculations of excess mortalities vary considerably depending on the method and its specification. Moreover, it is often unclear what exactly is meant by 'excess mortality'.
View Article and Find Full Text PDFNavigating the Science System: Research Integrity and Academic Survival Strategies.
Sci Eng Ethics
April 2024
Centre for Science and Technology Studies, Leiden University, Leiden, The Netherlands.
Research Integrity (RI) is high on the agenda of both institutions and science policy. The European Union as well as national ministries of science have launched ambitious initiatives to combat misconduct and breaches of research integrity. Often, such initiatives entail attempts to regulate scientific behavior through guidelines that institutions and academic communities can use to more easily identify and deal with cases of misconduct.
View Article and Find Full Text PDFIon-incorporated titanium implants for staged regulation of antibacterial activity and immunoregulation-mediated osteogenesis.
Nanoscale
April 2024
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China.
Antibacterial properties and osteogenic activity are considered as two crucial factors for the initial healing and long-term survivability of orthopedic implants. For decades, various drug-loaded implants to enhance biological activities have been investigated extensively. More importantly, to control the drug release timing is equally significant due to the sequential biological processes after implantation.
View Article and Find Full Text PDFGreen preferences sustain greenwashing: challenges in the cultural transition to a sustainable future.
Philos Trans R Soc Lond B Biol Sci
January 2024
Faculty of Business and Economics, University of Lausanne, Lausanne, 1015, Switzerland.
Discussions of the environmental impact that revolve around monetary incentives and other easy-to-measure factors are important, but they neglect culture. Pro-environmental values will be crucial when facing sustainability challenges in the Anthropocene, and demand among green consumers is arguably critical to incentivise sustainable production. However, owing to asymmetric information, consumers might not know whether the premium they pay for green production is well-spent.
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