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Exploration of the optimal programmed intermittent epidural bolus volume with the dural puncture epidural technique for labour analgesia: a biased-coin up-and-down sequential allocation study.

Can J Anaesth

February 2025

Department of Anesthesiology, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.

Purpose: To determine the optimal programmed intermittent epidural bolus (PIEB) volume for providing effective analgesia in 90% of patients (EV) during the first stage of labour using the dural puncture epidural (DPE) technique to initiate labour analgesia.

Methods: We conducted a biased-coin up-and-down sequential allocation study. We included 40 nulliparous women requiring epidural labour analgesia.

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It has been shown that various types of stress initiate different physiological and neuroendocrine disorders. Oxytocin (OT) is mainly produced in the supraoptic nucleus (SON) and paraventricular nucleus (PVN) of the hypothalamus. Hypothalamic OT has antistress effects and attenuates the hypothalamic-pituitary-adrenal (HPA) axis.

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[Incidence of epidural spread after Chayen's approach to lumbar plexus block: a retrospective study].

Braz J Anesthesiol

July 2021

Ospedali Riuniti Ancona, Department of Emergency, Anesthesia and Intensive care of Transplantation and Major Surgery, Ancona, Italy.

Background And Objectives: The lumbar plexus block (LPB) is a key technique for lower limb surgery. All approaches to the LPB involve a number of complications. We hypothesized that Chayen's approach, which involves a more caudal and more lateral needle entry point than the major techniques described in the literature, would be associated with a lower rate of epidural spread.

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Introduction: Spinal laminectomy is a common procedure performed to relieve neural compression in patients suffering from myelopathy or radiculopathy. However, up to 40% of patients suffer from persistent post-operative pain and disability, a condition known as Failed Back Surgery Syndrome (FBSS). Excessive scarring in the surgical bed is implicated as a cause.

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A Large Calvarial Bone Defect in a Child: Osseointegration of an Implant.

World Neurosurg

April 2019

Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland; Medical Research Center Oulu and PEDEGO Research Unit, University of Oulu, Oulu, Finland.

Background: This original report describes the outcome of a cranioplasty at long-term follow-up. A large calvarial bone defect of a child was reconstructed with a bioactive and biostable nonmetallic implant.

Case Description: In a child with infantile fibrosarcoma of occipital bone, the malignancy was removed at 2.

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