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Article Abstract
Acute pouchitis is the most common complication after a restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) for ulcerative colitis, affecting 40% of patients within the first year after surgery. Although up to 80% of patients can develop pouchitis symptoms, substantial gaps remain in our understanding of the epidemiology and burden of pouchitis. Administrative claims have been used to advance the knowledge of other areas of inflammatory bowel disease; however, a prerequisite to conducting such studies in pouchitis is a valid, reliable case-finding algorithm. Given concerns that the International Classification of Diseases (ICD) code for pouchitis may not be reliably used by clinicians (resulting in a low sensitivity), the objectives of the study were to (1) develop a series of case-finding definitions for acute pouchitis and (2) compare the performance of these case-finding definitions to that of a single ICD code for pouchitis.
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| http://dx.doi.org/10.1016/j.cgh.2020.03.003 | DOI Listing |
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Article Synopsis
- - Ulcerative colitis (UC) treatment includes both conventional and advanced options like biological therapies and small molecules; surgery, such as ileal pouch-anal anastomosis (IPAA), is recommended for severe cases but can lead to complications.
- - Chronic pouchitis, especially antibiotic-dependent (CADP) and antibiotic-refractory (CARP) types, poses significant treatment challenges due to insufficient evidence for effective options.
- - Promising results have been observed with biological therapies like vedolizumab and small molecules like JAK inhibitors; however, further quality research and clinical monitoring are necessary to establish reliable treatment guidelines.
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