Polymeric biomaterials capable of delivering nitric oxide (NO) topically can be used to enhance skin blood flow (SkBF) and accelerate wound healing. Herein, we used reversible addition-fragmentation chain transfer radical (RAFT) polymerization to synthesize the first poly(vinyl alcohol) (PVA) functionalized with terminal NO-releasing S-nitrosothiol (RSNO) groups for topical NO delivery. This strategy was based on the synthesis of a precursor amino-terminated PVA (PVA-NH), which was next functionalized with iminothiolane yielding 4-imino-4-amino-PVA-butane-1-thiol (PVA-SH), and finally S-nitrosated yielding S-nitroso 4-imino-4-amino-PVA-butane-1-thiol (PVA-SNO). Real-time chemiluminescence NO detection showed that blended films of pure PVA with PVA-SNO with mass ratios 30:70, 50:50 and 70:30 release NO with initial rates ranging from 1 to 12 nmol g min, and lead to a 2 to 10-fold dose-response increase in the SkBF, after topical application on the ventral forearm of volunteers. These results show that PVA-SNO is a potential platform for topical NO delivery in biomedical applications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.niox.2020.03.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploration of magnetic zeolite thin film derived from coal fly ash an efficient sorbent: Application to water treatment.
J Environ Manage
January 2025
Faculty of Geology, Geophysics and Environmental Protection, AGH University of Science and Technology, Al. Mickiewicza 30, 30-059, Krakow city, Poland.
Fly ash, produced during coal combustion for energy making, which is recognized as an industrial by-product, could lead to environmental health hazards. Subsequently, fly ash found that an exceptional adsorption performance for the removal of various toxic pollutants, the adsorption capacity of fly ash might be altered by introducing physical/chemical stimulation. Successfully converting fly ash into zeolites not only recovers their disposal difficulties but also transforms unwanted materials into merchandisable products for various industrial applications.
View Article and Find Full Text PDFLong-Lasting and High-Power-Density Yarn-Based Moisture-Enabled Electric Generator for Self-powered Electronic Textiles.
Small
January 2025
School of Materials & Energy, Southwest University, Chongqing, 400715, P. R. China.
1D moisture-enabled electric generators (MEGs) hold great promise for powering electronic textiles, but their current limitations in power output and operational duration restrict their application in wearable technology. This study introduces a high-performance yarn-based moisture-enabled electric generator (YMEG), which comprises a carbon-fiber core, a cotton yarn active layer with a radial gradient of poly(4-styrensulfonic acid) and poly(vinyl alcohol) (PSSA/PVA), and an aluminum wire as the outer electrode. The unique design maintains a persistent moisture gradient between the interior and exterior electrodes, enhancing performance through the continuous proton diffusion from PSSA and Al⁺ ions from the aluminum wire.
View Article and Find Full Text PDFHighly Elastic Spongelike Hydrogels for Impedance-Based Multimodal Sensing.
ACS Nano
January 2025
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Republic of Singapore.
Hydrogel-based sensors have been widely studied for perceiving the environment. However, the simplest type of resistive sensors still lacks sensitivity to localized strain and other extractable data. Enhancing their sensitivity and expanding their functionality to perceive multiple stimuli simultaneously are highly beneficial yet require optimal material design and proper testing methods.
View Article and Find Full Text PDFSynergy of Hydrophilic Properties and Antibacterial Inhibition in Polyvinyl Alcohol Nanofibrous Mats Loaded With Croton Bonplandianum Baill Leaf Extract.
Biopolymers
January 2025
Department of Textile Engineering, Dhaka University of Engineering and Technology, Gazipur, Dhaka, Bangladesh.
The antibacterial nanofibrous mat is crucial in biomedicine as it enhances infection control, expedites wound healing, and mitigates health hazards by decreasing antibiotic usage. A novel synergistic antibacterial and hydrophilic nanofibrous mat successfully fabricated by solution electrospinning from polyvinyl alcohol (PVA) incorporated Croton bonplandianum Baill (CBB) leaves extract. Antioxidant-enriched leaf extract of the CBB plant was integrated with PVA in varying proportions of 30% (CBB-30), 40% (CBB-40), and 50% (CBB-50) to manufacture antibacterial nanofibrous mat.
View Article and Find Full Text PDFPoly(vinyl alcohol) Embedded with Montmorillonite Clay and Nano Titania: A Scale-Up for Sustainable Environmental Remediation.
ACS Omega
December 2024
Department of Environmental Studies, Kannur University, Mangattuparamba Campus, Kannur, Kerala 670567, India.
A poly(vinyl alcohol)/montmorillonite/titania (PVA/MMT/TiO) nanocomposite film was fabricated via a simple solution casting strategy for the removal of cationic as well as anionic dyes. The developed nanocomposite film was subjected to X-ray diffraction (XRD), Fourier transform Infrared (FTIR), thermogravimetric analysis, dynamic mechanical analysis (DMA), mechanical property evaluation, and scanning electron microscopy (SEM) analysis. The embedding of MMT and TiO nanoparticles onto a PVA matrix has been confirmed from XRD, FTIR, and SEM analysis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!