Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jbspin.2020.02.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Total hip arthroplasty secondary to ocronotic arthropathy. A case report].
Acta Ortop Mex
January 2025
Universidad Anáhuac Querétaro, México.
Introduction: alkaptonuria is a rare hereditary metabolic disorder which is characterized by deficiency of the enzyme homogentisate 1,2 dioxygenase, which is responsible for the oxidation and renal elimination of homogentisic acid (HGA), which causes its accumulation. The excessive accumulation of HGA results in ochronosis and ochronotic arthropathy, which mainly affects the thoracolumbar spine and the large joints, leading to the need for joint replacement seeking to improve function and quality of life.
Clinical Case: hereby is presented a 67-years-old female patient with history of alkaptonuria with diffuse painful right hip of 4 years of evolution.
Anaesthesia Considerations in a Case of Alkaptonuria Posted for Total Knee Arthroplasty.
Cureus
June 2024
Orthopaedics, RNH Hospital Pvt. Ltd., Nagpur, IND.
Article Synopsis
- Alkaptonuria is a rare genetic disorder characterized by the buildup of homogentisic acid in collagenous tissues, resulting in discoloration and degeneration of joints, particularly affecting the spine and limbs.
- The condition can lead to pain, restricted mobility, and complications involving heart valves and kidneys, posing significant challenges in administering anesthesia.
- A report discusses the anesthetic management of a patient with alkaptonuria undergoing total knee arthroplasty, emphasizing the need for careful planning to address the unique difficulties presented.
Disc-coloration of an ochronotic cervical intervertebral disc in a patient with alkaptonuria: Case report and review of the literature.
Clin Neurol Neurosurg
July 2024
Department of Neurosurgery, Ziekenhuis Oost-Limburg, Genk 3600, Belgium.
Article Synopsis
- Alkaptonuria is a rare genetic disorder leading to the buildup of homogentisic acid, causing tissue damage and notable symptoms like ochronosis and spinal issues, particularly affecting the lumbar and occasionally cervical spine.
- A literature review was conducted on cervical spine changes in alkaptonuria patients, alongside the case of a 46-year-old with severe cervical spinal canal stenosis who underwent surgery for it.
- The study found no visible abnormalities during surgery except for a black discoloration of the intervertebral disc, indicating that such discoloration could signal potential alkaptonuria and warrant further investigation.
Arthroplasty in Ochronotic Arthropathy: 3 Replacements in a Single Patient with a Long-term Follow-up of 11 Years.
J Orthop Case Rep
February 2024
Department of Orthopaedics, Amandeep Hospital, Amritsar, Punjab, India.
Article Synopsis
- - Alkaptonuria is a rare genetic disorder that affects the metabolism of homogentisic acid, leading to a condition called ochronotic arthropathy, which impacts major joints like the spine and knees, often going undiagnosed until adulthood.
- - A case study details a 43-year-old man who was diagnosed with this condition during surgery and successfully underwent joint replacements in multiple areas over 10 years, maintaining full mobility without implant issues after 11 years.
- - The findings suggest that total joint arthroplasty can yield positive long-term outcomes for patients with ochronotic arthropathy, but surgeons must be vigilant about inherent surgical difficulties and potential complications during treatment.
Alkaptonuria Presenting With Lumbar Disc Herniation: A Case Report.
Cureus
August 2023
Department of Spine Services, Indian Spinal Injuries Centre, New Delhi, IND.
Alkaptonuria is a rare autosomal recessive trait. Symptomatic lumbar disc herniation warranting surgical intervention is a rare scenario in alkaptonuria and only a few cases have been described in the literature. We present one such rare case of alkaptonuria in a 31-year-old female presenting with low back pain and left leg radiculopathy not relieved with conservative management.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!