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Loss of core fucosylation suppressed the humoral immune response in Salmonella typhimurium infected mice. | LitMetric
Background : The humoral immune response is pivotal to protect the host from Salmonella typhimurium (S. typhimurium) infection. Previously, we found that core fucosylation catalyzed by core fucosyltransferase (Fut8) could regulate the immune responses. However, the role of core fucosylation during S. typhimurium infection remains unclear.Methods : To demonstrate the role of Fut8 in S. typhimurium infection, we infected Fut8 and Fut8 mice using S. typhimurium. The production of antiserum against the S. typhimurium was detected. The expression of T and B cell activation-related genes during S. typhimurium infection was analyzed. The role of core fucosylation on CD4 T-B cell interaction and B cell generation was investigated during S. typhimurium infection. The production of sIgA was compared between Fut8 and Fut8 mice.Results : Compared to Fut8 mice, the number of S. typhimurium colonized in the cecum was markedly increased in Fut8 mice. The production of the IgG and sIgA specific for S. typhimurium was significantly decreased in Fut8 mice. Moreover, loss of Fut8 decreased the induction of Th2-type cytokines from splenic cells of Fut8 mice during S. typhimurium infection. In addition, we found that the core fucosylation regulated the interaction between B and T cells in the lipid raft formation.Conclusion : Core fucosylation plays important roles in host defence against S. typhimurium infection.
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