Peroxynitrite (ONOO) plays a crucial role in the regulation of diverse pathophysiological processes, and high level of ONOO is profound association with numerous diseases. Herein, we developed an anthraquinone-based fluorescent probe L for ONOO determination by a new recognition mechanism: amido oxidized nitroso-group by ONOO. Probe L with amine-based recognition receptor is more selective to ONOO than other reactive oxygen species, including HO and ClO. Furthermore, ONOO could be rapidly detected by probe L with a Limit of Detection of 13 nM. More importantly, L could be used to monitor intracellular ONOO in SMMC-7721 cells.
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| http://dx.doi.org/10.1016/j.aca.2020.02.009 | DOI Listing |
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