AI Article Synopsis
- The study aimed to explore the link between the PLA2G7 gene polymorphisms (G994T and R92H) and the risk of developing preeclampsia (PE) in Chinese women, using a case-control design involving 273 PE patients and 530 healthy pregnant women.
- Significant findings showed that the G994T polymorphism was more common in PE patients, with the GT + TT genotype associated with a higher risk for PE even after adjusting for factors like age and BMI (odds ratio = 4.926).
- The study concluded that the G994T polymorphism increases the risk of preeclampsia, while the R92H polymorphism had no significant association.
Article Abstract
Objective: To investigate the relationship between platelet-activating factor acetylhydrolase (PAF-AH) gene (PLA2G7) G994T (V279F, rs76863441) and R92H (rs1805017) polymorphisms and risk of preeclampsia (PE) in Chinese women.
Study Design: This is a case-control study of 273 patients with PE and 530 healthy pregnant women.
Main Outcome Measures: PLA2G7 genotypes were determined by polymerase chain reaction amplification and restriction analysis. Plasma PAF-AH, apolipoprotein (apo) B-containing lipoprotein-associated PAF-AH (apoB-PAF-AH), total high-density lipoprotein (HDL)-associated PAF-AH (H-PAF-AH), apoE-containing HDL-associated PAF-AH (apoE-H-PAF-AH) activities, and clinical, metabolic, and oxidative stress parameters were also analyzed.
Results: The frequencies of the GT + TT genotype (14.7 versus 9.2%, P = 0.019) and T allele (7.5% versus 4.6%) of PLA2G7 G994T polymorphism were significantly higher in patients with PE than in the control subjects. The GT + TT genotypes remained a significant predictor for PE in a regression model including age, body mass index (BMI), plasma PAF-AH, H-PAF-AH, apoE-H-PAF-AH and apoB-PAF-AH activities as covariates (odds ratio (OR) = 4.926, 95% confidence interval (CI): 1.707-14.219, P = 0.003). The ratio of apoB-PAF-AH to H-PAF-AH activities was significantly higher, while serum triglyceride levels were lower in patients with the GT genotype compared with patients with the GG genotype (P < 0.05). No significant differences were observed in the frequencies of the R92H genotype and allele between the PE and control groups.
Conclusions: The PLA2G7 G994T, but not R92H, genetic polymorphism is associated with the risk of PE in Chinese women.
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| http://dx.doi.org/10.1016/j.preghy.2020.02.005 | DOI Listing |
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