Three hidden-charm pentaquark P_{c} states, P_{c}(4312), P_{c}(4440), and P_{c}(4457) were revealed in the Λ_{b}^{0}→J/ψpK^{-} process measured by LHCb using both run I and run II data. Their nature is under lively discussion, and their quantum numbers have not been determined. We analyze the J/ψp invariant mass distributions under the assumption that the crossed-channel effects provide a smooth background. For the first time, such an analysis is performed employing a coupled-channel formalism with the scattering potential involving both one-pion exchange as well as short-range operators constrained by heavy quark spin symmetry. We find that the data can be well described in the hadronic molecular picture, which predicts seven Σ_{c}^{(*)}D[over ¯]^{(*)} molecular states in two spin multiplets, such that the P_{c}(4312) is mainly a Σ_{c}D[over ¯] bound state with J^{P}=1/2^{-}, while P_{c}(4440) and P_{c}(4457) are Σ_{c}D[over ¯]^{*} bound states with quantum numbers 3/2^{-} and 1/2^{-}, respectively. We also show that there is evidence for a narrow Σ_{c}^{*}D[over ¯] bound state in the data which we call P_{c}(4380), different from the broad one reported by LHCb in 2015. With this state included, all predicted Σ_{c}D[over ¯], Σ_{c}^{*}D[over ¯], and Σ_{c}D[over ¯]^{*} hadronic molecules are seen in the data, while the missing three Σ_{c}^{*}D[over ¯]^{*} states are expected to be found in future runs of the LHC or in photoproduction experiments.
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http://dx.doi.org/10.1103/PhysRevLett.124.072001 | DOI Listing |
Cancer Cell
December 2024
Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA. Electronic address:
Molecular subtypes, such as defined by The Cancer Genome Atlas (TCGA), delineate a cancer's underlying biology, bringing hope to inform a patient's prognosis and treatment plan. However, most approaches used in the discovery of subtypes are not suitable for assigning subtype labels to new cancer specimens from other studies or clinical trials. Here, we address this barrier by applying five different machine learning approaches to multi-omic data from 8,791 TCGA tumor samples comprising 106 subtypes from 26 different cancer cohorts to build models based upon small numbers of features that can classify new samples into previously defined TCGA molecular subtypes-a step toward molecular subtype application in the clinic.
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January 2025
MultiplexDX, s.r.o., Comenius University Science Park, Bratislava, Slovakia.
Current assays fail to address breast cancer's complex biology and accurately predict treatment response. On a retrospective cohort of 1082 female breast tissues, we develop and validate mFISHseq, which integrates multiplexed RNA fluorescent in situ hybridization with RNA-sequencing, guided by laser capture microdissection. This technique ensures tumor purity, unbiased whole transcriptome profiling, and explicitly quantifies intratumoral heterogeneity.
View Article and Find Full Text PDFNat Commun
December 2024
Department of Theory and Bio-Systems, Max Planck Institute of Colloids and Interfaces, 14476, Potsdam, Germany.
Neurodegeneration in Huntington's disease (HD) is accompanied by the aggregation of fragments of the mutant huntingtin protein, a biomarker of disease progression. A particular pathogenic role has been attributed to the aggregation-prone huntingtin exon 1 (HTTex1), generated by aberrant splicing or proteolysis, and containing the expanded polyglutamine (polyQ) segment. Unlike amyloid fibrils from Parkinson's and Alzheimer's diseases, the atomic-level structure of HTTex1 fibrils has remained unknown, limiting diagnostic and treatment efforts.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
December 2024
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States.
Purpose: The retina contains the highest concentration of the omega 3 fatty acid, docosahexaenoic acid (DHA), in the body. Although epidemiologic studies showed an inverse correlation between the consumption of omega 3 fatty acids and the prevalence of diabetic retinopathy, there are no data showing the effect of diabetes on retinal DHA in humans. In this study, we measured the DHA content of the retina in diabetic and non-diabetic humans as well as mice and determined the effect of diabetes on retinal thickness and function in mice.
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December 2024
Center for Childhood Cancer Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA.
Patients with osteosarcoma (OS), a debilitating pediatric bone malignancy, have limited treatment options to combat aggressive disease. OS thrives on insulin growth factor (IGF)-mediated signaling that can facilitate cell proliferation. Previous efforts to target IGF-1R signaling were mostly unsuccessful, likely due to compensatory signaling through alternative splicing of the insulin receptor () to the proliferative isoform.
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