AI Article Synopsis
- The study presents a new method for electrochemically coupling amines with isocyanides to create carbodiimides without using metal catalysts or toxic chemicals.
- This reaction takes place in an undivided cell and produces hydrogen as the only byproduct, making it a safer and cleaner process.
- Additionally, the carbodiimides can be further transformed into unsymmetrical ureas using an electricity ON-OFF strategy, achieving moderate to good yields.
Article Abstract
This work discloses an electrochemical oxidative cross-coupling of amines with aryl and aliphatic isocyanides. In an undivided cell, the reaction proceeds without involving any transition-metal catalyst, oxidant, or toxic reagents providing carbodiimides in good yields, thereby circumventing stoichiometric chemical oxidants, with H as the only byproduct. Moreover, carbodiimides were in situ converted into unsymmetrical ureas in moderate to good yields using an electricity ON-OFF strategy.
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| http://dx.doi.org/10.1021/acs.orglett.0c00510 | DOI Listing |
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