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Neuropsychiatric manifestations following chimeric antigen receptor T cell therapy for cancer: a systematic review of clinical outcomes and management strategies.
J Immunother Cancer
December 2024
Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany.
Background: Chimeric antigen receptor (CAR)-T cell therapy has emerged as a transformative modality in the treatment of patients with cancer. However, it is increasingly evident that this therapeutic approach is not without its challenges. The unique nature of CAR-T cells as living drugs introduces a distinct set of side effects.
View Article and Find Full Text PDFProgressive Cachexia: Tuberculosis, Cancer, or Thyrotoxicosis? Disease-Directed Therapy and Atypical Courses of Autoimmune and Malignant Thyroid Diseases in a High Specialization Era: Case-Control Study with a Critical Literature Review.
Biomedicines
November 2024
Department of Pharmacognosy and Herbal Medicines, Wroclaw Medical University, 50-367 Wrocław, Poland.
Critical and progressive cachexia may be observed in numerous medical disciplines, but in patients with various diseases, several pathways overlap (endocrine, inflammatory and kidney diseases, heart failure, cancer). Unlike numerous cohort studies that examine thyroid cancer and risk factors, a different method was used to avoid bias and analyze the sequence of events, i.e.
View Article and Find Full Text PDFAssociation between the geriatric nutritional risk index and postoperative delirium in gastric surgery patients: an analysis of the MIMIC-IV database.
BMC Anesthesiol
December 2024
Department of Anesthesiology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350014, Fujian Province, China.
Background: This study explores the correlation between nutritional status, as determined by the Geriatric Nutritional Risk Index (GNRI), and the incidence of postoperative delirium (POD) in patients undergoing gastric surgery.
Methods: Data were obtained from the MIMIC-IV 2.2 database for patients aged 18 years or older who underwent gastric surgery.
Accumulating the key proteomic signatures associated with delirium: Evidence from systematic review.
PLoS One
December 2024
NHMRC Clinical Trials Centre, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.
Article Synopsis
- Delirium is a serious neuropsychiatric condition seen often in intensive care and post-surgery, leading to longer hospital stays and higher mortality/morbidity rates.
- A systematic review analyzed 1746 studies on delirium biomarkers from 2000-2023, resulting in the inclusion of 78 studies emphasizing proteomic signatures related to the condition.
- The review identified 313 proteins, with a focus on 13 key proteins (like IL-6, CRP, and TNF-a) that show a significant link to delirium, highlighting the need for more research to better understand these biomarkers for diagnosis and treatment.
Methodological expectations for demonstration of health product effectiveness by observational studies.
Therapie
December 2024
University Grenoble Alpes, Inserm, CIC1406, HP2 U1300, CHU Grenoble Alpes, 38043 Grenoble, France. Electronic address:
The issue of assessing the effectiveness of health technologies (drugs, devices, etc.) through observational studies is becoming increasingly important as registration and market access agencies consider them in their evaluation process. In this context, observational studies must be able to provide real demonstrations of a level of reliability comparable to those produced by the conventional randomized controlled trial (RCT) approach.
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