[RENOPROTECTIVE EFFECT OF THE BIOTRIT MUCOSO-ADHESIVE PHYTOGEL IN RATS, RECEIVING ORAL APPLICATIONS OF OXIDIZED SUNFLOWER OIL].

Oral applications of peroxidised sunflower oil (PSO) cause development of nephropathy, which can be prevented with the help of oral applications of the Biotrit phytogel containing bioflavonoids from wheat seedlings. The purpose of this work was to determine the renoprotective effect of the Biotrit phytogel under the influence of PSO on rats. The experiments were carried out on 18 white Wistar rats (females, 4-5 months, 210±12 g), divided into 3 equal groups: the first - control, received compound feed. The 2nd and 3rd groups received the same diet; however, they additionally undergo oral applications of PSO at a dose of 0.5 ml per rat daily for 5 days. Rats of the 3rd group 30 minutes before the application of PSO received application of the "Biotrit" gel in a dose of 0.5 ml per rat for 5 days. After euthanasia of animals, kidneys were removed on the 6th day and the level of biochemical markers of inflammation and the content of malonic dialdehyde (MDA), urease and lysozyme were determined in the homogenate of the latter. Under the action of PSO both indicators significantly increase: elastase activity by 20%, and MDA content by 50%. Oral applications of the "Biotrit" gel reduce both indicators of inflammation. Catalase activity does not change both with the introduction of PSO and after application of the Biotrit gel. In rats treated with PSO, urease activity in the kidneys significantly increases, indicating an increase in bacterial contamination, which decreases under the influence of oral applications of the Biotrit gel. The consumption of peroxidised fats causes the development of nephropathy in experimental animals. To prevent the development of peroxide nephropathy, one can use oral applications of "Biotrit" phytogel.