AI Article Synopsis
- The article discusses a multicenter study in Russia on infective endocarditis, focusing on the causes, antibiotic effectiveness, and drug usage patterns.
- The study analyzed 406 cases, finding that 35.5% had identifiable pathogens, primarily gram-positive cocci, with Staphylococcus aureus being the most common at 46.5%.
- The research highlighted the frequent use of aminoglycosides and third-generation cephalosporins in initial treatment, while adjustments in therapy often involved glycopeptides and fluoroquinolones.
Article Abstract
The article presents the results of a multicenter study of the etiology, antibiotic sensitivity and pharmacoepidemiology of infective endocarditis in the Russian Federation. The purpose of this study is to analyze the current practice of management of patients with infective endocarditis in conditions of low frequency of etiologically significant pathogens in the Russian Federation. The study included patients of both sexes of all age groups with definite and probable infective endocarditis. 406 cases of infectious endocarditis (240 in retrospect and 166 in the prospective part) were analyzed. Etiologically significant pathogen was isolated in 144 cases (35.5%). The structure of pathogens was dominated by gram (+) cocci (90.3%), most often - Staphylococcus aureus (46.5% of all isolated pathogens). Aminoglycosides (22.8%), parenteral cephalosporins of the III generation (22.1%) and glycopeptides (14.5%) were most frequently used in the course of starting antimicrobial therapy. When changing the mode of antimicrobial therapy, glycopeptides (18.6%), aminoglycosides (15.3%), fluoroquinolones (11.2%) and parenteral cephalosporins of generation III (9.5%) were most often prescribed.
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