Communicated by Ramaswamy H. Sarma.
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Green development strategy for efficient quercetin- loaded whey protein complex: Focus on quercetin loading characteristics, component interactions, stability, antioxidant, and in vitro digestive properties.
Food Chem
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College of Food Science, Northeast Agricultural University, Harbin 150030, China. Electronic address:
This study aimed to develop a quercetin-loaded whey protein complex using pH-induced co-assembly for the intestinal-targeted delivery of quercetin. The investigation focused on quercetin loading capacity, formation mechanism, stability, antioxidant activity, and in vitro digestive properties of the complex. The results indicated that the stable complex was obtained at a quercetin-to-protein mass ratio of 1:20, exhibiting a high encapsulation efficiency (96.
View Article and Find Full Text PDFpH-induced conformational changes in the selectivity filter of a potassium channel lead to alterations in its selectivity and permeation properties.
Front Pharmacol
January 2025
IDiBE-Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche, Universidad Miguel Hernández, Elche, Spain.
The Selectivity Filter (SF) in tetrameric K channels, has a highly conserved sequence, TVGYG, at the extracellular entry to the channel pore region. There, the backbone carbonyl oxygens from the SF residues, create a stack of K binding sites where dehydrated K binds to induce a conductive conformation of the SF. This increases intersubunit interactions and confers a higher stability to the channel against thermal denaturation.
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Sci Adv
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Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Otto-Hahn-Str. 11, 44227 Dortmund, Germany.
Article Synopsis
- Tc toxins are harmful proteins from bacteria that can pierce cell membranes, allowing them to introduce toxic enzymes into cells.
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Molecular Dynamics Simulation on the Conformational Change of a pH-Switchable Lipid.
Langmuir
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State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng 252059, China.
pH-sensitive lipids are important components of lipid nanoparticles, which enable the targeted delivery and controlled release of drugs. Understanding the mechanism of pH-triggered drug release at the molecular level is important for the rational design of ionizable lipids. Based on a recently reported pH-switchable lipid, named SL2, molecular dynamics (MD) simulations were employed to explore the microscopic mechanism behind the membrane destabilization induced by the conformational change of pH-switchable lipids.
View Article and Find Full Text PDFGroundwater hydrogeochemistry and potential health risk assessment through exposure to elevated arsenic in Darrang district of north bank plain of the Brahmaputra.
Sci Rep
December 2024
Centre for Ecology, Environment and Sustainable Development, Tata Institute of Social Sciences, Guwahati, Assam, 781013, India.
The current study investigates groundwater contamination in Darrang district, situated in the flood-prone Brahmaputra Valley. This research evaluates the concentrations and geospatial distributions of iron, fluoride, and arsenic in groundwater samples (n = 347) and assesses their potential ecotoxicological risks to human health. Multivariate statistical techniques were used to investigate the sources and the mobilization mechanism of the contaminants in the aquifer system.
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