AI Article Synopsis
- Hypersensitivity pneumonitis (HP) is a prevalent yet often overlooked lung disease linked to environmental or occupational exposure to organic allergens, and this study explored the presence of specific IgG antibodies (ssIgG) in HP patients and their clinical relevance.
- The study involved 128 HP patients and a control group of 102 patients with other interstitial lung diseases, assessing their serum for antibodies related to certain antigens, particularly from birds and thermophilic actinomycetes.
- Findings revealed that 57% of HP patients had positive ssIgG results, especially in those exposed to birds, highlighting the potential of ssIgG as a diagnostic tool, while suggesting that molds might play a role in HP for patients exposed
Article Abstract
Introduction: Hypersensitivity pneumonitis (HP) is the third most common interstitial lung disease, and is often under-recognized, especially in patients who are not aware of their occupational or environmental contact with organic antigens. The aim of the present study was to assess the results of serum specific IgG antibodies (ssIgG) in HP patients and their correlation with clinical data.
Material And Methods: 128 HP patients, median age 53 years, participated in the study. The control group consisted of 102 patients with interstitial lung diseases (ILDs) other than HP. Assessment of pretreatment ssIgG to thermophilic actinomycetes and protein antigens from bird droppings (pigeons, hens, ducks, parrots, turkeys) was performed by double diffusion in agar gel according to Ouchterlony method.
Results: Positive precipitins were obtained in 57% of all HP patients and in 61% of those exposed to above mentioned antigens. Positive results in the control group were obtained in 7% of patients. Sensitivity of ssIgG in HP group was 0.57 and specificity 0.93. Precipitins to at least one bird antigen was confirmed in 64% of HP patients exposed to birds. Precipitins to thermophilic bacteria were found in 29% of HP patients exposed to hay or hay products.
Conclusions: The results of the study indicate that ssIgG against birds' allergens were the valuable diagnostic tool in HP patients. Low-rate of confirmation of ssIgG to thermophilic bacteria in patients exposed to hay or hay products indicate that other microorganisms, most likely molds, could be responsible for the disease development.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050063 | PMC |
| http://dx.doi.org/10.5114/ceji.2019.92791 | DOI Listing |
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