A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 143

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3098
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: Attempt to read property "Count" on bool

Filename: helpers/my_audit_helper.php

Line Number: 3100

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3100
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

In vivo mitochondrial and glycolytic impairments in patients with Alzheimer disease. | LitMetric

In vivo mitochondrial and glycolytic impairments in patients with Alzheimer disease.

Neurology

From the Department of Biofunctional Imaging (T.T., T.B., T.M., Y.O.), Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine; Department of Neurology (T.T., T.O., T.M.), Shizuoka Institute of Epilepsy and Neurological Disorders; and Central Research Laboratory (E.Y., I.A., M.F., H.T.), Hamamatsu Photonics KK; and Hamamatsu PET Imaging Center (I.A., M.F.), Hamamatsu Medical Photonics Foundation, Japan.

Published: April 2020

AI Article Synopsis

  • This study investigates how glucose metabolism and mitochondrial activity differ in the brains of Alzheimer's patients, focusing on a new PET probe ([F]BCPP-EF) that measures mitochondrial complex-I activity.
  • Researchers found that mitochondrial activity was significantly lower in the parahippocampus of Alzheimer's patients, indicating a failure in oxidative metabolism compared to normal controls.
  • The findings suggest that mitochondrial dysfunction occurs before issues with glucose metabolism in early-stage Alzheimer's, highlighting its role in the disease's progression.

Article Abstract

Objective: In vivo glycolysis-related glucose metabolism and electron transport chain-related mitochondrial activity may be different regionally in the brains of patients with Alzheimer disease (AD). To test this hypothesis regarding AD pathophysiology, we measured the availability of mitochondrial complex-I (MC-I) with the novel PET probe [F]2-tert- butyl-4-chloro-5-2H- pyridazin-3-one ([F]BCPP-EF), which binds to MC-I, and compared [F]BCPP-EF uptake with F-fluorodeoxyglucose ([F]FDG) uptake in the living AD brain.

Methods: First, the total distribution volume (V) of [F]BCPP-EF from 10 normal controls (NCs) was quantified using arterial blood samples and then tested to observe whether V could substitute for the standard uptake value relative to the global count (SUVRg). Eighteen NCs and 14 different NCs underwent PET with [F]BCPP-EF or [F]FDG, respectively. Second, 32 patients with AD were scanned semiquantitatively with double PET tracers. Interparticipant and intraparticipant comparisons of the levels of MC-I activity ([F]BCPP-EF) and glucose metabolism ([F]FDG) were performed.

Results: The [F]BCPP-EF V was positively correlated with the [F]BCPP-EF SUVRg, indicating that the use of the SUVRg was sufficient for semiquantitative evaluation. The [F]BCPP-EF SUVRg, but not the [F]FDG SUVRg, was significantly lower in the parahippocampus in patients with AD, highlighting the prominence of oxidative metabolic failure in the medial temporal cortex. Robust positive correlations between the [F]BCPP-EF SUVRg and [F]FDG SUVRg were observed in several brain regions, except the parahippocampus, in early-stage AD.

Conclusions: Mitochondrial dysfunction in the parahippocampus was shown in early-stage AD. Mitochondria-related energy failure may precede glycolysis-related hypometabolism in regions with pathologically confirmed early neurodegeneration in AD.

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000009249DOI Listing

Publication Analysis

Top Keywords

[f]bcpp-ef suvrg
12
[f]bcpp-ef
9
patients alzheimer
8
alzheimer disease
8
glucose metabolism
8
suvrg [f]fdg
8
[f]fdg suvrg
8
parahippocampus early-stage
8
suvrg
7
[f]fdg
5

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: