AI Article Synopsis
- Young mammals can regenerate certain tissues, but this ability decreases as they mature, possibly due to cellular senescence.
- In a study of liver regeneration after partial hepatectomy, specific senescence-associated genes (p21, p16, p19) were found to be expressed differently in various cell types as regeneration capacity diminished.
- Treatment with a drug that inhibits senescence improved liver regeneration by reducing prolonged p21 expression, indicating that targeting cellular senescence may help enhance organ regeneration in young mammals.
Article Abstract
Young mammals possess a limited regenerative capacity in some tissues, which is lost upon maturation. We investigated whether cellular senescence might play a role in such loss during liver regeneration. We found that following partial hepatectomy, the senescence-associated genes p21, p16, and p19 become dynamically expressed in different cell types when regenerative capacity decreases, but without a full senescent response. However, we show that treatment with a senescence-inhibiting drug improves regeneration, by disrupting aberrantly prolonged p21 expression. This work suggests that senescence may initially develop from heterogeneous cellular responses, and that senotherapeutic drugs might be useful in promoting organ regeneration.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111259 | PMC |
| http://dx.doi.org/10.1101/gad.332643.119 | DOI Listing |
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