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Efficacy of Lurasidone in First-Episode Psychosis: Patient Phenotypes, Dosage, and Recommendations from an Expert Panel.
Neurol Ther
January 2025
Department of Psychiatry, Faculty of Medicine, Mental Health Unit, Virgen del Rocio University Hospital, Translational Psychiatry Group, IBiS-CSIC, CIBERSAM, University of Seville, Seville, Spain.
Introduction: For patients with psychosis, early, intensive therapeutic intervention is thought to improve long-term outcomes. Furthermore, patients with a first-episode psychosis (FEP) who experience a good early response to antipsychotic medication show a clinical and functional benefit over the longer term if they continue low-dose antipsychotic treatment. Lurasidone is an atypical antipsychotic agent which is approved in Europe for the treatment of schizophrenia in adults and adolescents (13-17 years).
View Article and Find Full Text PDFInorganic/Inorganic Composites Through Emulsion Templating.
Adv Mater
December 2024
Centre for Advanced Structural Ceramics, Department of Materials, Imperial College London, London, SW7 2AZ, UK.
Inorganic/inorganic composites are found in multiple applications crucial for the energy transition, from nuclear reactors to energy storage devices. Their microstructures dictate their properties from mass transport to fracture resistance. Consequently, there has been a multitude of processes developed to control them, from powder mixing and the use of short or long fibers, to tape casting for laminates up to recent 3D printing.
View Article and Find Full Text PDFMacrophages are activated toward phagocytic lymphoma cell clearance by pentose phosphate pathway inhibition.
Cell Rep Med
December 2024
Department I of Internal Medicine, Centre for Integrated Oncology (CIO) Aachen-Bonn-Cologne-Duesseldorf, University Hospital Cologne, 50937 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, 50937 Cologne, Germany. Electronic address:
Macrophages in the B cell lymphoma microenvironment represent a functional node in progression and therapeutic response. We assessed metabolic regulation of macrophages in the context of therapeutic antibody-mediated phagocytosis. Pentose phosphate pathway (PPP) inhibition induces increased phagocytic lymphoma cell clearance by macrophages in vitro, in primary human chronic lymphocytic leukemia (CLL) patient co-cultures, and in mouse models.
View Article and Find Full Text PDFGeneration of a Mouse Model for the Study of Thyroid Hormones Regulatory Effect on the Immune System.
Methods Mol Biol
November 2024
Unidad de Oncogenómica, Servicio de Oncohematología, Fundación para la Investigación Biomédica del Hospital Universitario Niño Jesús, Madrid, Spain.
The generation of hypothyroid and hyperthyroid mouse models is one of the approaches used to investigate the complex interplay between thyroid hormones and the immune system. We present a detailed protocol describing how to induce endotoxic shock by lipopolysaccharide (LPS) administration, and how to investigate the role of immune populations, specifically macrophages, responding to endotoxemia.This book chapter provides the use of different molecular techniques, such as Western Blotting, Immunohistochemistry, q-PCR, Luciferase assays, or ChIP assays, with which researchers can gain valuable insights into the immune system's interaction with hormonal signaling pathways, for instance, examining the effect of thyroid hormones on signaling of STAT3, NF-κB, and ERK in response to LPS, and inflammatory mediators, such as interleukin-6 (IL-6) or tumor necrosis factor-alpha (TNFα) within these cells.
View Article and Find Full Text PDFMetabolic balance of a marine neritic copepod under chronic and acute warming scenarios.
Mar Environ Res
January 2025
Institut de Ciències del Mar (ICM), CSIC, Pg. Marítim de la Barceloneta 37-49, 08003 Barcelona, Spain. Electronic address:
We investigated the impact of sublethal thermal stress on physiological rates of the copepod Paracartia grani, and explored the influence of previous thermal history on this response. The copepods, originally reared at 19 °C, were raised for 23 generations at 22 °C and 25 °C, and posteriorly exposed for 7-d to stress temperature (28 °C). The copepod acclimation capacity was assessed by comparing metabolic balance at 28 °C against their respective rearing temperatures.
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