AI Article Synopsis
- Researchers developed a glucose-responsive insulin delivery system using a multi-enzyme metal-organic framework (MOF) integrated with microneedles for painless diabetes treatment.
- The system utilizes glucose oxidase (GOx) to convert glucose into gluconic acid, which lowers the local pH, triggering the release of preloaded insulin.
- This innovative approach effectively minimizes the release of harmful byproducts while ensuring the microneedles can penetrate the skin efficiently, showcasing a promising method for transdermal drug delivery.
Article Abstract
Elaborately designed glucose-responsive insulin-delivery systems are highly desirable for the treatment of diabetes because it can secrete insulin depending on blood glucose levels. Herein, mimic multi-enzyme metal-organic framework (MOF)-based (insulin and glucose oxidase-loaded cobalt-doped ZIF-8, abbreviated as Ins/GOx@Co-ZIF-8) stimuli-responsive microneedles (MNs) were designed for painless glucose-mediated transdermal administration. In this work, GOx and Co ions were engineered into MOFs to construct a mimic multi-enzyme vehicle. GOx in the MOF, as the glucose-responsive factor, could catalyze glucose into gluconic acid with the formation of HO as the byproduct. The gluconic acid formed decreases the local pH in MOFs, resulting in the degradation of MOFs and thus preloaded insulin would be released. Meanwhile, catalyzed by Co ions in the MOF, the byproduct HO was decomposed. Possible free Co ions would be chelated by EDTA-SiO nanoparticles in MNs and removed by peeling MNs off. The as-obtained mimic multi-enzyme MOF-based MNs showed good dependence on glucose concentration without divulging HO and Co ions and enough stiffness to penetrate into skin. This study offers a new strategy, using facilely synthesized MOFs as depots to integrate with MNs, for designing stimuli-responsive transdermal drug-delivery systems.
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| http://dx.doi.org/10.1021/acsami.9b20774 | DOI Listing |
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