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Clozapine-induced cholinergic urticaria: a case report.
Ther Adv Psychopharmacol
May 2024
Établissement public de santé mentale de Ville Evrard, France.
Article Synopsis
- - Clozapine is effective for treatment-resistant schizophrenia but carries serious side effects like hematological issues and myocarditis, alongside less severe but impactful dermatological reactions.
- - A 25-year-old male experienced cholinergic urticaria—intense itching and redness triggered by sweating—after four months on clozapine, which impaired his daily life despite treatment adjustments.
- - Switching from clozapine to quetiapine resulted in improvement, highlighting the need for personalized treatment plans and the importance of managing side effects, even those that appear after an extended period.
Optimizing co-prescription of clozapine and antiseizure medications: a systematic review and expert recommendations for clinical practice.
Expert Opin Drug Metab Toxicol
May 2024
Mental Health Research Center at Eastern State Hospital, Lexington, USA.
Introduction: Antiseizure medication (ASM) add-on to clozapine may be efficient to target clozapine-resistant mood or psychotic symptoms or clozapine-related adverse drug reactions (ADR) such as seizures. We aimed to synthesize the information relevant for clinical practice on the risks and benefits of clozapine-ASM co-prescription.
Areas Covered: Articles were identified with MEDLINE, Web of Sciences and PsycINFO search from inception through October 2023.
Clozapine-induced pneumonitis mimicking an atypical pneumonia.
BMJ Case Rep
March 2024
General Medicine, Gold Coast University Hospital, Southport, Queensland, Australia.
Clozapine is an antipsychotic used for treatment-resistant schizophrenia with a significant side effect profile, including agranulocytosis, myocarditis and fever. Clozapine-induced fever often occurs in the first 2 weeks of treatment and settle after a few days. We report a case of a woman in her mid-30s who developed fever and infective symptoms suggestive of an atypical pneumonia while on clozapine titration.
View Article and Find Full Text PDFStructural basis of ligand recognition and design of antihistamines targeting histamine H receptor.
Nat Commun
March 2024
Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Article Synopsis
- - The histamine H receptor (HR) is crucial for immune cell function and is a significant target for treating allergies and inflammation, but detailed structural information has been lacking.
- - This study presents four cryo-EM structures of HR/G complexes with different ligands, revealing a unique ligand binding mode that involves specific residues (D94 and E182) crucial for receptor activation.
- - The findings help identify mutations that can change how ligands interact with the receptor, paving the way for designing new, more effective antihistamines targeting HR.
DRESS to loxapine and avoidable recurrence with clozapine.
Contact Dermatitis
February 2024
Service de Dermatologie, Hôpital Henri Mondor, AP-HP, Créteil, France.
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