It is important to clarify the significance of long noncoding RNA MIR31 host gene (lncRNA ) in predicting the prognosis for malignant tumors through meta-analysis. Electronic databases were systemically searched, from inception until 2 January 2019, to identify related articles. Meanwhile, the hazard ratios (odds ratios) and 95% CIs were computed for exploring the association between the expression of lncRNA and the survival (pathological variables). Eleven studies with 1041 cases were enrolled into the current meta-analysis. Low expression of lncRNA showed correlation with the dismal overall survival, disease-free survival, high tumor stage and lymph node metastasis among patients with digestive system cancers. Low expression of lncRNA may serve as a potential novel factor to indicate the dismal prognosis and metastasis in patients with digestive system cancers.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/bmm-2019-0145 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Research progress of non-coding RNA regulating the role of PANoptosis in diabetes mellitus and its complications.
Apoptosis
January 2025
Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Diabetes is a chronic metabolic disease that is endemic worldwide and is characterized by persistent hyperglycemia accompanied by multiple severe complications, including cardiovascular disease, kidney dysfunction, neuropathy, and retinopathy. The pathogenesis of diabetes mellitus and its complications is multifactorial, involving various molecular and cellular pathways. In recent years, research has indicated that mechanisms of cell death play a significant role in the advancement of diabetes and its complications.
View Article and Find Full Text PDFDrought is one of the main environmental factors affecting plant survival and growth. Atraphaxis bracteata is a common desert plant mainly utilized in afforestation and desertification control. This study analyzed the morphological, physiological and molecular regulatory characteristics of different organs of A.
View Article and Find Full Text PDFRibosome profiling reveals dynamic translational landscape in HEK293T cells following X-ray irradiation.
Genomics
January 2025
Department of Clinical Laboratory of Sir Run-Run Shaw Hospital, and School of Public Health, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address:
X-ray irradiation induces widespread changes in gene expression. Positioned at the bottom of the central dogma, translational regulation responds swiftly to environmental stimuli, fine-tuning protein levels. However, the global view of mRNA translation following X-ray exposure remains unclear.
View Article and Find Full Text PDFLong non-coding RNA XR008038 promotes the myocardial ischemia/reperfusion injury development through increasing the expressions of galectin-3.
Int J Cardiol
January 2025
Department of Intensive Care Unit, Hangzhou Hospital of Traditional Chinese Medicine (Dingqiao District), Guangxing Affiliated Hospital of Zhejiang Chinese Medical University, No.453 Tiyuchang Road, Hangzhou, Zhejiang 310013, China. Electronic address:
Background: Myocardial ischemia/reperfusion (I/R) injury is a common pathophysiological change after myocardial reperfusion therapy. Recent research confirmed that long non-coding RNA (IncRNAs) played an important role in many cardiovascular diseases. This study was carried out to explore the role of lncRNA XR008038 in the I/R progression.
View Article and Find Full Text PDFLncRNA-MEG3/miR-93-5p/SMAD7 axis mediates proliferative and inflammatory phenotypes of fibroblast-like synoviocytes in rheumatoid arthritis.
Int J Biol Macromol
January 2025
Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; The Grade 3 Pharmaceutical Chemistry Laboratory of State Administration of Traditional Chinese Medicine, Hefei 230022, China. Electronic address:
Synovial hyperplasia, inflammation and immune cell infiltration are the central pathological basis of rheumatoid arthritis (RA). Nonetheless, the cellular, molecular and immunological mechanisms of RA remain poorly understood. An integrated analysis of single-cell RNA (scRNA) and bulk RNA sequencing datasets aimed to unravel the cellular landscape, differentiation trajectory, transcriptome signature, and immunoinfiltration feature of RA synovium.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!