Background: Studies have shown that number transcoding abilities (ie, translating numbers from one numerical code to another) are affected early in the development of Alzheimer disease (AD). However, no study has extensively explored how these abilities are affected in individuals with mild cognitive impairment (MCI).
Objective: To determine the contribution that number transcoding tasks make to the identification of MCI, and to pinpoint the cognitive correlates of performance in these tasks.
Methods: We compared the performance of 20 individuals with the amnestic subtype of MCI, eight individuals with AD, and 20 healthy controls on three number transcoding tasks.
Results: The results confirmed the presence of number transcoding impairment in the individuals with AD. The individuals with MCI were found to be impaired in two of the transcoding tasks; these individuals produced perseverations of the input code-the most noteworthy error type in individuals with AD. In addition, the relationship between impairment in attentional and executive functions and impairment in number transcoding was supported by the correlational analyses.
Conclusions: This study confirmed that number transcoding abilities are impaired in individuals with MCI, although less severely than in individuals with AD. Our results provide evidence for the clinical value of including number transcoding tasks in the assessment of cognitive deficits associated with pathological aging.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/WNN.0000000000000225 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Deficits in or Preservation of Basic Number Processing in Parkinson's Disease? A Registered Report.
J Neurosci Res
November 2024
Department of Psychology, University of Tuebingen, Tuebingen, Germany.
Neurodegenerative diseases such as Parkinson's disease (PD) have a huge impact on patients, caregivers, and the health care system. Until now, diagnosis of mild cognitive impairments in PD has been established based on domain-general functions such as executive functions, attention, or working memory. However, specific numerical deficits observed in clinical practice have not yet been systematically investigated.
View Article and Find Full Text PDFThe effect of inverting decades and units on the retention of two-digit numbers in working memory: a matter of the output mode.
Psychol Res
November 2024
The Edmond J Safra Brain Research Centre for the Study of Learning Disabilities, University of Haifa, Haifa, Israel.
Number-word structure affects transcoding and relates to working memory capacity (WMc). We tested the relationship between the structure of number-words (inverted "Units-Decades (UD) format" or not "Decades-Units (DU) format") and performance on the digit span task for recalling two-digit number-words presented verbally, using two modes of output. University students, native speakers of Arabic, who were also highly proficient in Hebrew, and native speakers of Hebrew, were asked to response by typing Arabic digits or recalling numbers verbally.
View Article and Find Full Text PDFThinking about numbers in different tongues: An overview of the influences of multilingualism on numerical and mathematical competencies.
Psychol Res
November 2024
Institute of Cognitive Science and Assessment, Department of Behavioural and Cognitive Sciences, Faculty of Humanities, Education and Social Sciences, University of Luxembourg, Belval Esch-sur-Alzette, Luxembourg.
In an increasingly multilingual and multicultural world, understanding the interactions between language and mathematics is critical, especially when individuals must acquire and exercise their mathematical competencies in multiple languages. Indeed, research shows that, overall, L2 language learners are at an academic disadvantage compared to their L1 peers. The current article briefly overviews how multilingualism influences basic and advanced mathematical skills and interacts with mathematical learning difficulties.
View Article and Find Full Text PDFDevelopment of a crosswalk to convert French PCS2003 into international ISCO88 occupational classifications. Application to the Occupational Asthma-specific Job-Exposure Matrix (OAsJEM).
Ann Work Expo Health
August 2024
Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d'Épidémiologie Respiratoire Intégrative, CESP, 94807 Villejuif, France.
Article Synopsis
- Researchers faced challenges linking job data from different classifications to the Occupational Asthma-specific Job-Exposure Matrix (OAsJEM), which uses the ISCO88 classification, necessitating the development of a crosswalk for the CONSTANCES cohort coded with PCS2003.
- The crosswalk was created through a collaborative effort involving skilled and novice coders who developed strategies to convert jobs from PCS2003 to ISCO88, refining their results through consensus meetings.
- The finalized crosswalk established 998 job matches, revealing significant variability in the initial proposals from different coders and showcasing the complexity in transcoding occupational classifications.
POLARIS: A phase 2 trial of encorafenib plus binimetinib evaluating high-dose and standard-dose regimens in patients with V600-mutant melanoma with brain metastasis.
Neurooncol Adv
March 2024
Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Background: POLARIS (phase 2 [ph2]; NCT03911869) evaluated encorafenib (BRAF inhibitor) in combination with binimetinib (MEK1/2 inhibitor) in BRAF/MEK inhibitor-naïve patients with V600-mutant melanoma with asymptomatic brain metastases.
Methods: The safety lead-in (SLI) assessed tolerability for high-dose encorafenib 300 mg twice daily (BID) plus binimetinib 45 mg BID. If the high dose was tolerable in ph2, patients would be randomized to receive high or standard dose (encorafenib 450 mg once daily [QD] plus binimetinib 45 mg BID).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!