AI Article Synopsis
- The study aimed to assess changes in applicator and prostate geometry in patients undergoing high-dose-rate brachytherapy (HDR-BT) over a three-day period and determine if daily replanning was necessary.
- Analysis of 18 patients showed that without replanning, the effectiveness of the treatment dramatically decreased by the second day, affecting both the targeted area and surrounding tissues.
- The findings suggest that to maintain accurate and effective HDR-BT, daily replanning is essential, as changes are significant as early as day two.
Article Abstract
Background: The present study aimed to estimate geometric changes in applicators and prostate over 3 days in patients with high-dose-rate brachytherapy (HDR-BT) and to assess the need for daily replanning.
Patients And Methods: This study retrospectively investigated 18 patients who underwent HDR-BT as monotherapy from February 2016 to October 2018.
Results: Without replanning, the planning target volume coverage significantly worsened on day 2 (p<0.001) and day 3 (p=0.003). The minimum dose distributed to the highest irradiated rectal volume of 5 cc became significantly higher on day 2 (p=0.02), and the maximum dose distributed to the urethra became significantly higher on day 2 (p=0.01).
Conclusion: Conformal, high-dose delivery of HDR-BT is impaired without replanning not only on the second day but also on the third day. Daily replanning is required for achieving accuracy of HDR-BT.
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| http://dx.doi.org/10.21873/anticanres.14119 | DOI Listing |
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