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Raman active diyne-girder conformationally constrained p53 stapled peptides bind to MDM2 for visualisation without fluorophores.
RSC Chem Biol
January 2025
School of Chemistry, Advanced Research Centre, University of Glasgow 11 Chapel Lane Glasgow G11 6EW UK
Peptide stapling is an effective strategy to stabilise α-helical peptides, enhancing their bioactive conformation and improving physiochemical properties. In this study, we apply our novel diyne-girder stapling approach to the MDM2/MDMX α-helical binding region of the p53 transactivation domain. By incorporation of an unnatural amino acid to create an optimal , + 7 bridge length, we developed a highly α-helical stapled peptide, 4, confirmed circular dichroism.
View Article and Find Full Text PDFOn-Surface Synthesis and Characterization of Pentadecacene and Its Gold Complexes.
J Am Chem Soc
January 2025
Philipps-Universität Marburg, Fachbereich Chemie, Hans-Meerwein-Str. 4, 35032 Marburg, Germany.
Acenes are an important class of polycyclic aromatic hydrocarbons that have gained considerable attention from chemists, physicists, and material scientists, due to their exceptional potential for organic electronics. They serve as an ideal platform for studying the physical and chemical properties of sp carbon frameworks in the one-dimensional limit and also provide a fertile playground to explore magnetism in graphenic nanostructures due to their zigzag edge topology. While higher acenes up to tridecacene have been successfully generated by means of on-surface synthesis, it is imperative to extend their synthesis toward even longer homologues to comprehensively understand the evolution of their electronic ground state.
View Article and Find Full Text PDFTetra-Cationic Distibane Stabilized by Bis(α-iminopyridine) and Its Reactivity.
J Am Chem Soc
January 2025
Department of Chemistry, Indian Institute of Science Education and Research, Pune, Dr. Homi Bhabha Road, Pashan, Pune 411008, Maharashtra, India.
The work establishes the salt of a tetra-cationic distibane, [LSb][CFSO] = [][OTf] (CFSO = OTf), stabilized by a bis(α-iminopyridine) ligand , defying the Coulombic repulsion. The synthetic approach involved a dehydrocoupling reaction when a mixture of and Sb(OTf) in a 1:1 ratio was treated with EtSiH/LiBEtH as the hydride source. Compound [][OTf] was also achieved from [LSbCl][OTf] as a precursor and using EtSiH.
View Article and Find Full Text PDFStretchable microwave absorbers (SMAs) are vital for flexible electronics. Traditional SMAs display unstable tensile properties resulting from inconsistencies between the constrained conductive layer and the flexible dielectric layer. This study introduces an organohydrogel-based stretchable microwave absorber (OSMA) that incorporates an organohydrogel within an island-bridge structure.
View Article and Find Full Text PDFA DIY Bioreactor for in Situ Metabolic Tracking in 3D Cell Models via Hyperpolarized C NMR Spectroscopy.
Anal Chem
January 2025
Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.
Nuclear magnetic resonance (NMR) spectroscopy is a valuable diagnostic tool limited by low sensitivity due to low nuclear spin polarization. Hyperpolarization techniques, such as dissolution dynamic nuclear polarization, significantly enhance sensitivity, enabling real-time tracking of cellular metabolism. However, traditional high-field NMR systems and bioreactor platforms pose challenges, including the need for specialized equipment and fixed sample volumes.
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