ENY2 protein of Drosophila melanogaster was previously discovered and characterized in our laboratory [1, 2]. It was found that ENY2 is a subunit of several multiprotein complexes and connects various stages of gene expression [3-5]. This work is devoted to studying the interaction of ENY2 with RNA helicase MLE. This interaction was confirmed by independent methods. Data indicating that this interaction is conserved in evolution and is important for the functioning of MLE in both sexes were obtained.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1134/S1607672919060140 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Drosophila melanogaster Paip2 Binds ENY2 and Interacts with the TREX-2 Complex in Histone mRNP Particles].
Mol Biol (Mosk)
December 2024
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia.
ENY2 is an evolutionarily conserved multifunctional protein and is a member of several complexes that regulate various stages of gene expression. ENY2 is a subunit of the TREX-2 complex, which is necessary for the export of bulk mRNA from the nucleus to the cytoplasm through the nuclear pores in many eukaryotes. The wide range of ENY2 functions suggests that it can also associate with other protein factors or complexes.
View Article and Find Full Text PDFTREX-2-ORC Complex of D. melanogaster Participates in Nuclear Export of Histone mRNA.
Dokl Biochem Biophys
February 2024
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
The TREX-2-ORC protein complex of D. melanogaster is necessary for the export of the bulk of synthesized poly(A)-containing mRNA molecules from the nucleus to the cytoplasm through the nuclear pores. However, the role of this complex in the export of other types of RNA remains unknown.
View Article and Find Full Text PDFInteraction of mRNA with the C-Terminal Domain of PCID2, a Subunit of the TREX-2 Complex, Is Required for Its Export from the Nucleus to the Cytoplasm in Drosophila melanogaster.
Dokl Biochem Biophys
December 2023
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Following the transcription step, the newly synthesized mRNA is exported from the nucleus to the cytoplasm and further to the translation site. The TREX-2 complex is involved in the step of mRNA export from the nucleus to the cytoplasm. This complex in Drosophila melanogaster consists of four proteins: Xmas-2, PCID2, ENY2, and Sem1p.
View Article and Find Full Text PDFThe Xmas-2 Protein of Drosophila melanogaster Undergoes Cleavage into Two Fragments.
Dokl Biochem Biophys
April 2023
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
The TREX-2 complex integrates several stages of gene expression, such as transcriptional activation and mRNA export. In D. melanogaster, TREX-2 consists of four major proteins: Xmas-2, ENY2, PCID2, and Sem1p.
View Article and Find Full Text PDFAn integrative analysis of enhancer of yellow 2 homolog (ENY2) as a molecular biomarker in pan-cancer.
Funct Integr Genomics
March 2023
Department of Surgery, Division of Life Science and Medicine, Anhui Provincial Hospital, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China.
ENY2 (Enhancer of yellow 2 transcription factor) is a transcription nuclear protein and primarily participates in the course of mRNA export and histone deubiquitination to influence gene expression. Current studies have shown that the expression of ENY2 is significantly upregulated in multiple cancers. However, the exact association between ENY2 and pan-cancers has not been fully established.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!