Purpose: Prolonged endotracheal intubation may lead to laryngeal damage, with stridor being the most relevant clinical symptom. Our objective was to determine the incidence of post-extubation stridor and their clinical consequences in children within a tertiary referral center and to identify contributing factors.
Methods: 150 children, aged 0-16 years, intubated for more than 24 h were prospectively enrolled until discharge of the hospital. Potential relevant factors, thought to mediate the risk of laryngeal damage, were recorded and analyzed.
Results: The median duration of intubation was 4 days, ranging from 1 to 31 days. Stridor following extubation occurred in 28 patients (18.7%); 3 of them required reintubation due to respiratory distress and in 1 child stridor persisted for which a surgical intervention was necessary. In multivariate analyses, we found the following independent predictors of stridor: intubation on the scene, the use of cuffed tubes and lower age.
Conclusion: Despite a high incidence for post-extubation stridor, only few children need reintubation or surgical intervention as a result of post-extubation lesions. Intubation on the scene, the use of cuffed tubes and young age are associated with a significant increased risk of post-extubation stridor. Awareness of these factors gives the possibility to anticipate on the situation and to minimize laryngeal injury and its possible future consequences.
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http://dx.doi.org/10.1007/s00405-020-05877-0 | DOI Listing |
Cureus
October 2024
Pulmonary and Critical Care, University of Oklahoma Health Sciences Center, Oklahoma, USA.
Front Pediatr
July 2024
Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, Nijmegen, Netherlands.
Introduction: Critically ill patients show large variability in drug disposition due to e.g., age, size, disease and treatment modalities.
View Article and Find Full Text PDFBraz J Otorhinolaryngol
May 2024
Universidade Estadual de Campinas (UNICAMP), Hospital de Clínicas, Campinas, SP, Brazil.
Objectives: To make recommendations on the diagnosis and treatment of post-extubation laryngitis (PEL) in children with or without other comorbidities.
Methods: A three-iterative modified Delphi method was applied. Specialists were recruited representing pediatric otolaryngologists, pediatric and neonatal intensivists.
Eur Arch Otorhinolaryngol
June 2024
Department of Otorhinolaryngology, Erasmus Medical Center, Sophia Children's Hospital, Room SP 1421a, Dr Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands.
Indian J Pediatr
August 2024
Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Guwahati, India.
This study aimed to determine the effect of protocolized sedation using the COMFORT-B scale on the duration of mechanical ventilation (DMV). Eighty children with anticipated Duration of mechanical ventilation (DMV) >24 h admitted to the Pediatric intensive care unit (PICU) were randomized into one group that received protocolized sedation (PS) using the COMFORT behavioural (COMFORT-B) scale, and another group that received non-protocolized sedation (NPS). The primary outcome was the impact on the DMV.
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