The case of an 82-year-old woman with bilateral necrotizing fasciitis and unilateral orbital involvement is presented. A mixed infection consisting of Streptococcus pyogenes, Staphylococcus aureus, and Aspergillus fumigatus could be verified. The latter was detected by molecular pathological investigations. Treatment consisted of repeated surgical debridement in combination with systemic broad-spectrum antibiotic and antimycotic treatment. Furthermore, the patient received low-dose systemic corticosteroids. After remission of acute inflammation, the healing process by secondary intention was uneventful.
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