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Dimericchalasine A and Amichalasines D and E: Unexpected Cytochalasan Homodimer and Heterotrimers from PG-1. | LitMetric

Dimericchalasine A and Amichalasines D and E: Unexpected Cytochalasan Homodimer and Heterotrimers from PG-1.

Org Lett

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Published: March 2020

The study of led to the isolation of three unprecedented cytochalasans (-). Dimericchalasine A () is the first cytochalasan homodimer fused by a C-20/C-20' single bond. Amichalasines D () and E () represent a new type of cytochalasan heterotrimer with a decacyclic 5/6/11/5/5/6/5/12/6/5 ring system. Their structures were determined by extensive spectroscopic data and single-crystal X-ray diffraction. The plausible biosynthetic pathways of - were proposed.

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Source
http://dx.doi.org/10.1021/acs.orglett.0c00141DOI Listing

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