AI Article Synopsis
- PRP is a treatment for joint issues, and this study examined its effects using different types obtained from young and old donors in aged rats.
- The study involved six months of injections, followed by bone analysis through micro-CT and histology, revealing that PRP from older donors had higher proinflammatory molecules.
- Results indicated that young donor PRP led to better bone structure, suggesting it can help combat age-related bone degeneration and support bone health.
Article Abstract
Platelet-rich plasma (PRP) is an increasingly widespread treatment for joint pathologies. Its characteristics and administration route are variables that may influence the clinical outcome. The aim of this in vivo study was to analyze in aged rats the biological and structure effects of intraosseous infiltrations of two different types of PRP obtained from young and old donors. During 6 months intraosseous infiltrations were performed and 4 days after the last infiltration, animals were sacrificed, and bones were extracted for micro-computed tomography (micro-CT) and histological analysis. Molecular composition of the PRP of aged donors presented higher levels of proinflammatory molecules. The histological studies showed a greater cellularity of bone marrow in groups treated with PRP. Concerning micro-CT analysis, young PRP showed a better femoral bone structure according to values of percentage of trabecular bone, trabecular space, trabecular density, and subchondral bone plate volume. In summary, this study has demonstrated that intraosseous infiltrations of PRP from young donors prevent from age-related bone degeneration. This treatment could stimulate the biological processes that maintain homeostasis and bone structure and avoid osteoarticular pathologies.
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| http://dx.doi.org/10.1002/jor.24646 | DOI Listing |
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Article Synopsis
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