AI Article Synopsis
- The hydration state of metal ions in a specific coiled coil structure can be adjusted from fully hydrated to nearly dry by selecting different terminal residues, including tryptophan (Trp).
- This tuning ability allows for precise control over the number of aqua ligands attached to the metal.
- A significant outcome of this tuning could be a four-fold increase in MRI relaxivity when using lanthanide ions within these coiled coils.
Article Abstract
The metal hydration state within a designed coiled coil can be progressively tuned across the full integer range (3 → 0 aqua ligands), by careful choice of a second sphere terminal residue, including the lesser used Trp. Potential implications include a four-fold change in MRI relaxivity when applied to lanthanide coiled coils.
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| http://dx.doi.org/10.1039/c9cc08189e | DOI Listing |
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