Purpose: A recent 3-month randomized, open-label controlled trial found that the intra-articular hyaluronic acid injection (GO-ON) given as a single dose of 5 mL is as effective and safe as three repeated doses of 2.5 mL in patients with knee osteoarthritis. However, the information on the long-term efficacy and economic implications of the single-dose regimen is still limited. Hence, this follow-up study was designed to compare the effectiveness and costs of the two regimens 12 months following the treatment.
Methods: All the 127 patients, who received either three repeated doses ( = 64) or a single dose ( = 63) of GO-ON in the previous trial, were followed up in month 12 following the treatment. The effectiveness of both the regimens was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the mean WOMAC scores were compared with those recorded at the baseline and in month 3. Additionally, the total treatment costs of the two regimens, taking account of both direct and indirect costs, were computed and compared.
Results: A total of 125 patients (98.4%) completed the assessment. Despite the reduction of the overall mean WOMAC score from 39.24 to 19.93 ( < 0.001) in the first 3 months following the treatment with GO-ON, no further changes were observed up to month 12 ( > 0.95). In the meantime, the two regimens did not differ in the mean WOMAC scores ( = 0.749) and in the subscale scores for pain ( = 0.970), stiffness ( = 0.526), and physical functioning ( = 0.667) in month 12. The cost for single-dose injection was found to be approximately 30% lower compared to the repeated doses.
Conclusion: These findings indicate that the single larger dose of GO-ON is as effective as the repeated doses over 12 months, and yet the total treatment cost is lowered.
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http://dx.doi.org/10.1177/2309499019895029 | DOI Listing |
J Appl Toxicol
December 2024
School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, China.
Dihydroartemisinin (DHA) is an effective antimalarial drug with potential antitumor efficacy, yet toxicological information is limited. The present study was designed to evaluate the potential toxicity of oral DHA. DHA was administered orally by gavage to SD rats at doses of 0, 25, 50, and 75/60 mg/kg b.
View Article and Find Full Text PDFNeurol Ther
December 2024
Axoltis Pharma, Bioparc Laennec, 60 Avenue Rockefeller, 69008, Lyon, France.
Introduction: Blood-brain barrier (BBB) integrity is fundamental to brain homeostasis, enabling control of substance exchange and safeguarding neurons against harmful toxins, pathogens, and immune cells that lead to dysregulation and inflammation involved in ageing and neurodegenerative diseases (NDD). The cyclized peptide NX210c is a thrombospondin type 1 repeat analogue derived from subcommissural organ-spondin. It exerts beneficial effects in animal models of NDD owing to its effects on neurons and endothelial cells.
View Article and Find Full Text PDFDiabetes Ther
December 2024
Novo Nordisk A/S, Vandtårnsvej 108-110, 2860, Søborg, Denmark.
Introduction: The glucagon-like peptide-1 (GLP-1) analogue semaglutide is approved as an oral formulation for the treatment of type 2 diabetes. This study aimed to confirm bioequivalence between a new, second-generation (2G) oral semaglutide formulation (1.5, 4 and 9 mg) and the initially approved first-generation (1G) formulation (3, 7 and 14 mg).
View Article and Find Full Text PDFLancet Glob Health
January 2025
Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; WHO Collaborating Centre, Karolinska University Hospital, Stockholm, Sweden.
Background: Optimising management of second-trimester medical abortion is important, as complications increase with gestational age. We aimed to compare a 24-h interval with a 48-h interval between mifepristone intake and misoprostol administration in in-hospital, second-trimester medical abortion for effectiveness and acceptability.
Methods: This open-label, randomised, controlled, non-inferiority trial was conducted at nine hospitals in India, Sweden, Thailand, and Viet Nam among adults undergoing medical abortion for a singleton viable pregnancy at a gestation of between 9 weeks and 20 weeks.
Anim Reprod Sci
December 2024
University of Calgary Faculty of Veterinary Medicine, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada. Electronic address:
This review focuses on bull breeding behaviors and management strategies to improve reproductive efficiency. Breeding soundness evaluations are utilized to classify a bull's physical ability and sperm quality, yet roughly 20 % of bulls fail to meet the minimum criteria. Furthermore, despite achieving the minimum criteria, few bulls in multi-sire breeding groups sire the majority of calves, indicating a need for better understanding of bull behavior that impact siring capacity, and thus, a bull's reproductive efficiency.
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