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[Immune checkpoint inhibitors and renal toxicity : update about an emerging pathology]. | LitMetric

[Immune checkpoint inhibitors and renal toxicity : update about an emerging pathology].

Rev Med Suisse

Service de néphrologie et hypertension, CHUV, 1011 Lausanne.

Published: February 2020

Recently, comprehension of immune mechanisms involved in anti-tumor responses has permitted the development of new oncologic drugs called immune checkpoint inhibitors. These drugs act by restoring anti-tumor responses. With their increasing use, we note a rise in the incidence rate of immune related adverse events, which can affect many organs. Renal toxicity, more precisely tubulointerstitial nephritis, is still not well understood but an emerging complication.

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