Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.hjc.2020.02.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The interdependent hemodynamic influence between abdominal aortic aneurysm and renal artery stenosis.
Sci Rep
December 2024
Department of Biomedical Engineering, National University of Singapore, Block E7 #06-02, 15 Kent Ridge Cres, Singapore, 119276, Singapore.
Cardiovascular diseases remain a leading cause of morbidity and mortality worldwide with abdominal aortic aneurysm (AAA) and renal artery stenosis (RAS) standing out as significant contributors to the vascular pathology spectrum. While these conditions have traditionally been approached as distinct entities, emerging evidence suggests a compelling interdependent relationship between AAA and RAS, challenging the conventional siloed understanding. The confluence of AAA and RAS represents a complex interplay within the cardiovascular system, one that is often overlooked in clinical practice and research.
View Article and Find Full Text PDFFecal microbiota transplantation validates the importance of gut microbiota in an ApoE mouse model of chronic apical periodontitis-induced atherosclerosis.
BMC Oral Health
November 2024
Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatology Key lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.
Article Synopsis
- - This study explores the link between chronic apical periodontitis (CAP) and atherosclerosis, specifically looking at how disruptions in gut microbiota influence this relationship through metabolites like trimethylamine N-oxide (TMAO).
- - By conducting fecal microbiota transplantation from CAP-affected mice to healthy ones, researchers found that the transplanted mice developed more atherosclerotic lesions despite no significant changes in lipid or inflammatory factors in their serum.
- - Key findings include an increased ratio of Firmicutes to Bacteroidetes in the gut microbiota of atherosclerosis-affected mice, indicating that specific gut bacteria may play a role in the severity of atherosclerosis linked to CAP, independent of traditional cardiovascular
Novel therapeutic targets for atherosclerosis: Targeting the FOSB-MECP2-Commd1 pathway.
Int Immunopharmacol
January 2025
Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China. Electronic address:
Atherosclerosis (AS) is a systemic disease and represents the primary underlying pathology of cardiovascular diseases. In this study, we aim to elucidate the roles of FBJ osteosarcoma oncogene B (FOSB) in AS development. ApoE mice were used and fed a high-fat diet to establish an AS model.
View Article and Find Full Text PDFInvestigating the role of thrombosis and false lumen orbital orientation in the hemodynamics of Type B aortic dissection.
Sci Rep
November 2024
Department of Mechanical Engineering, University of Maryland, College Park, MD, 20742, USA.
While much about the fundamental mechanisms behind the initiation and progression of Type B aortic dissection (TBAD) is still unknown, predictive models based on patient-specific fluid-structure interaction (FSI) simulations can help in risk stratification and optimal clinical decision-making. Aiming at the development of personalized treatment, FSI models can be leveraged to investigate the interplay between complex aortic flow patterns and anatomical features, while considering the deformation of the arterial wall and the dissection flap. In this study, the hemodynamics of false lumen thrombosis, a large fenestration, and the orbital orientation of the false lumen is studied through image-based FSI simulations on three TBAD patient-specific geometries.
View Article and Find Full Text PDFEpigenetic modulation of vascular calcification: Looking for comprehending the role of sirt1 and histone acetylation in VSMC phenotypic transition.
Exp Cell Res
November 2024
Program in Environmental and Experimental Pathology, Paulista University, São Paulo, 04026-002, São Paulo, Brazil; Graduate Program in Health Sciences, University of Taubaté, Taubaté, SP, 12020-340, Brazil. Electronic address:
In light of the complex origins of ectopic vascular calcification and its significant health implications, this study offers a comprehensive exploration of the molecular dynamics governing vascular smooth muscle cells (VSMCs). Focusing on epigenetic modulation, we investigate the transition from a contractile to a calcifying phenotype in VSMCs, with an emphasis on understanding the role of SIRT1. For this purpose, a single batch of human aortic SMCs, used at a specified passage number to maintain consistency, was subjected to calcium and phosphate overload for up to 72 h.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!