biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against nondividing spp. HT61 was effective at reducing biofilm viability and was associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for biofilm infections.
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| http://dx.doi.org/10.1128/AAC.02073-19 | DOI Listing |
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