We report on Czochralski growth, detailed ground- and excited-state absorption and emission spectroscopy and highly-efficient mid-infrared (∼2.3 µm) laser operation of a cubic potassium yttrium fluoride crystal, Tm:KYF. The peak stimulated-emission cross-section for the H → H transition is 0.34×10 cm at 2345 nm with an emission bandwidth exceeding 50 nm. The excited-state absorption spectra for the F → F and F → H transitions are measured and the cross-relaxation is quantified. A continuous-wave 5 at.% Tm:KYF laser generated 0.84 W at 2331-2346 nm by pumping at 773 nm, with a record-high slope efficiency of 47.7% (versus the incident pump power) owing to the efficient action of energy-transfer upconversion leading to a pump quantum efficiency approaching 2. The first Tm:KYF laser with ESA-assisted upconversion pumping (at 1048 nm) is also demonstrated. Due to its broadband emission properties, Tm:KYF is promising for ultrashort pulse generation at ∼2.3-2.4 µm.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1364/OE.382650 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Single-molecule two- and three-colour FRET studies reveal a transition state in SNARE disassembly by NSF.
Nat Commun
January 2025
State Key Laboratory of Membrane Biology, Beijing Frontier Research Center of Biological Structure, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.
SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptor) proteins are the minimal machinery required for vesicle fusion in eukaryotes. Formation of a highly stable four-helix bundle consisting of SNARE motif of these proteins, drives vesicle/membrane fusion involved in several physiological processes such as neurotransmission. Recycling/disassembly of the protein machinery involved in membrane fusion is essential and is facilitated by an AAA+ ATPase, N-ethylmaleimide sensitive factor (NSF) in the presence of an adapter protein, α-SNAP.
View Article and Find Full Text PDFO304 alleviates abdominal aortic aneurysm formation via AMPK/mTOR/MMP pathway activation.
Front Pharmacol
November 2024
Department of Vascular Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China.
Background: Abdominal aortic aneurysm (AAA) rupture is a significant cause of mortality in the elderly population. Despite experimental models identifying promising pharmacological therapies, there is still a lack of pharmacological interventions for AAA prior to surgery. This study aims to evaluate the regulatory role of the novel adenosine monophosphate-activated protein kinase (AMPK) agonist O304 in AAA formation and explore its underlying molecular mechanisms.
View Article and Find Full Text PDFOverexpressing the ClpC AAA+ unfoldase accelerates developmental cycle progression in .
mBio
January 2025
Department of Pathology, Microbiology, and Immunology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
is an obligate intracellular bacterium that undergoes a complex biphasic developmental cycle, alternating between the smaller, infectious, non-dividing elementary body (EB) and the larger, non-infectious but dividing reticulate body. Due to the differences between these functionally and morphologically distinct forms, we hypothesize protein degradation is essential to chlamydial differentiation. The bacterial Clp system, consisting of an ATPase unfoldase (e.
View Article and Find Full Text PDFOn the specificity of the recognition of m6A-RNA by YTH reader domains.
J Biol Chem
December 2024
Department of Biochemistry, University of Zurich, Zurich, Switzerland.
Most processes of life are the result of polyvalent interactions between macromolecules, often of heterogeneous types and sizes. Frequently, the times associated with these interactions are prohibitively long for interrogation using atomistic simulations. Here, we study the recognition of N6-methylated adenine (mA) in RNA by the reader domain YTHDC1, a prototypical, cognate pair that challenges simulations through its composition and required timescales.
View Article and Find Full Text PDFTransmission line model as a digital twin for abdominal aortic aneurysm patients.
NPJ Digit Med
October 2024
Mechanical Engineering, University of Maryland, College Park, MD, 20742, USA.
We investigated the potential of the transmission line model as a digital twin of aneurysmal aorta by comparatively analyzing how a uniform lossless tube-load model were fitted to the carotid and femoral artery tonometry waveforms pertaining to (i) 79 abdominal aortic aneurysm (AAA) patients vs their matched controls (CON) and (ii) 35 AAA patients before vs after endovascular aneurysm repair (EVAR). The uniform lossless tube-load model fitted the tonometry waveforms pertaining to AAA as well as CON and EVAR. In addition, the parameters in the tube-load model exhibited physiologically explainable changes: when normalized, both pulse transit time and reflection coefficient increased with AAA and decreased after EVAR, which can be explained by the increase in arterial compliance and the decrease in arterial inertance due to the aortic expansion associated with AAA.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!