Unlabelled: To evaluate the risk of colorectal cancer (CRC) after cholecystectomy for gallbladder stones (GBS).
Methods: This nationwide population-based cohort study analyzed the inpatient data from the Taiwan National Health Insurance Research Database. The study cohort comprised of 83,963 patients aged 20 years undergoing cholecystectomy for GBS between 2000 and 2010. The control cohort comprised the GBS patients without cholecystectomy, who were propensity matched with the study cohort at a 1:1 ratio based on age, sex, comorbidities, and the index date for cholecystectomy.
Results: The cumulative incidence of CRC within 6 months of follow-up was higher in the cholecystectomy cohort than that in the non-cholecystectomy cohort (aHR (adjusted hazard ratio) = 7.90, 95% confidence interval (CI) = 6.27-9.94; log-rank test, < 0.001). The cumulative incidence of CRC after 6 months of follow-up was lower in the cholecystectomy cohort than that in the non-cholecystectomy cohort (aHR = 0.66, 95% CI = 0.60-0.73; log-rank test, < 0.001), but the reduced risk of CRC for the cholecystectomy cohort was statistically significant only in rectal cancer after separately considering females (aHR = 0.64, 95% CI = 0.46-0.88) and males (aHR = 0.59, 95% CI = 0.44-0.79).
Conclusions: The positive association between cholecystectomy and the CRC risk within the first 6 months after cholecystectomy might be due to a detection bias or pre-existing CRC. However, cholecystectomy is associated with a decreased risk of rectal cancer, rather than proximal or distal colon cancer, after more than 6 months of follow-up.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139669 | PMC |
| http://dx.doi.org/10.3390/cancers12030550 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cholecystectomy Is a Risk Factor for Proximal Colon Cancer That May Also Relate to its Aggressiveness.
J Surg Res
December 2024
Department of Rheumatology, Hospital Angeles Chihuahua, Chihuahua, Mexico.
Introduction: There are studies with mixed conclusions about the role cholecystectomy plays as a risk factor for proximal colorectal cancer (CRC).
Methods: We performed a multicenter retrospective cohort study where the records of patients with CRC were reviewed. Data was collected regarding affected colon subsegment (cecum, ascending, transverse, descending, sigmoid, or rectum, which were also combined into proximal or distal colon), history and time since cholecystectomy, histopathology reports (TNM classification and clinical stage), and KRAS, NRAS, and BRAF mutation analysis.
Effect of smoking on the risk of gastrointestinal cancer after cholecystectomy: A national population-based cohort study.
World J Gastrointest Surg
September 2024
Division of Hepatobiliary-Pancreas Surgery and Liver Transplantation, Department of Surgery, St Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon 16247, South Korea.
Background: The role of smoking in the incidence of colorectal cancer (CRC) or gastric cancer (GC) in populations undergoing cholecystectomy has not been investigated.
Aim: To evaluate the effect of smoking on CRC or GC development in cholecystectomy patients.
Methods: A total of 174874 patients who underwent cholecystectomy between January 1, 2010 and December 31, 2017 were identified using the Korean National Health Insurance Service claims database.
Alteration of ascending colon mucosal microbiota in patients after cholecystectomy.
World J Gastrointest Surg
August 2024
Department of Gastroenterology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201803, China.
Article Synopsis
- Cholecystectomy, a surgery for treating gallstones, may lead to an increased risk of colorectal cancer (CRC) in patients, possibly linked to changes in gut microbiota.
- A study involving 30 post-cholecystectomy patients and 28 healthy controls analyzed mucosal biopsy samples using advanced sequencing techniques to examine the bacterial communities.
- The findings revealed that older post-cholecystectomy patients had different gut microbiota compositions and higher levels of certain beneficial bacteria, suggesting potential implications for CRC treatment and gastrointestinal issues following surgery.
The impact of long-term (≥5 years) cholecystectomy on gut microbiota changes and its influence on colorectal cancer risk: based on 16S rDNA sequencing analysis.
Eur J Gastroenterol Hepatol
November 2024
Department of General Surgery, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
Background: Colorectal cancer (CRC) continues to be a major global health concern. Recent advances in molecular biology have highlighted the gut microbiota's role in CRC. This study investigates long-term (≥5 years) gut microbiota changes in patients postcholecystectomy, comparing them with CRC patients and healthy controls to assess their impact on CRC development.
View Article and Find Full Text PDFTreatment Outcomes of Incidental Gallbladder Cancer - Results from a High-Volume Tertiary Care Centre in North India.
Indian J Surg Oncol
May 2024
Department of Surgical Oncology, King George's Medical University, Lucknow, 226003 India.
Article Synopsis
- Gallbladder cancer (GBC) is often diagnosed incidentally (IGBC) and offers a chance for early intervention, leading to improved patient outcomes.
- A study analyzed 125 IGBC patients from a database at a tertiary care center in India, revealing that over half were ineligible for surgery, but almost 70% of those who could undergo surgery had successful outcomes.
- Factors influencing operability include gallbladder wall thickness and time to treatment, highlighting the importance of early detection and referral for better survival rates.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!