Genetic causes of PD: A pathway to disease modification.

Neuropharmacology

Department of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, London, United Kingdom. Electronic address:

Published: June 2020

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Article Abstract

The underline neuropathology of Parkinson disease is pleiomorphic and its genetic background diverse. Possibly because of this heterogeneity, no effective disease modifying therapy is available. In this paper we give an overview of the genetics of Parkinson disease and explain how this is relevant for the development of new therapies. This article is part of the special issue entitled 'The Quest for Disease-Modifying Therapies for Neurodegenerative Disorders'.

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http://dx.doi.org/10.1016/j.neuropharm.2020.108022DOI Listing

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